ArticleBMC oral health2025
Effects of combining hyaluronic acid hydrogel with injectable platelet rich fibrin on apical papilla stem cells proliferation and differentiation.
Article in BMC oral health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
2 citing papers in PubMed.
- κ-Carrageenan-Based Hydrogels Support Viability and Odontogenic Differentiation of Stem Cells From the Apical Papilla.International dental journal · 2026Article
- Serum-Integrated Dopamine-Hyaluronic Acid Hydrogels for Injectable Soft-Tissue Microenvironment Modulation.Macromolecular bioscience · 2026Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThis study examines the effects of combining hyaluronic acid hydrogel (HA) and injectable platelet-rich fibrin (iPRF) on the proliferation, migration and odontogenic differentiation of apical papilla stem cells (SCAP). The goal is to enhance regenerative endodontic procedures (REPs) with more effective regenerative biomaterials.
methodSCAPs were cultured on HA, both with and without iPRF in a 3D culture system. Also, the effect of iPRF in a 2D culture was assessed. Cell proliferation was evaluated using MTT assay, for analysing cell migration the Transwell Migration assay was utilized. To assess the odontogenic differentiation, the alkaline phosphatase assay was performed, and the gene expression of odontogenic markers including Collagen type I (Col-1), Dentin matrix protein1 (DMP-1), and Dentin sialophosphoprotein (DSPP) were examined by real-time Polymerase chain reaction (PCR).
resultsiPRF induced cell proliferation in 2D and HA 3D cultures compared to the control groups. The HA/iPRF mixture showed synergistic effects in odontogenic gene expression and migration assays. However, the iPRF group showed the most alkaline phosphatase expression after 7 days. Cells in a 3D culture system combining HA and iPRF demonstrated enhanced odontogenic differentiation and chemotaxis compared to either component used separately.
conclusionThe combination of HA and iPRF shows promise for future regenerative endodontic applications.
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