ArticleBMC musculoskeletal disorders2025
Exploring heat shock protein-related biomarkers and subgroups in osteoarthritis using Gene Expression Omnibus data sets.
Article in BMC musculoskeletal disorders, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Senescence-associated gene pathways are differentially expressed in equine aging-related osteoarthritis.American journal of veterinary research · 2026Article
- Artemisia-derived carbon dots with excellent pharmacological activities and ROS scavenging for osteoarthritis treatment.Journal of nanobiotechnology · 2026Article
- ER-resident proteins are key players in cartilage and bone homeostasis.Frontiers in cell and developmental biology · 2025Review
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Authors and funding
6 authors.
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Abstract
Osteoarthritis (OA) is a degenerative joint disease marked by cartilage deterioration. Recent studies suggest that heat shock proteins (HSPs) may play a role in the pathophysiology of OA. This study explores the role of heat shock protein-related genes (HSRs) in OA using GEO datasets (GSE12021, GSE55457, GSE55235). Differential expression analysis identified 34 HSRs with significant changes in OA. Protein-protein interaction (PPI) network analysis highlighted central HSRs, including HSPA5, HSPA6, HSPA1L, HSPA12 A, and HSPH1, indicating their key roles in OA. Enrichment analysis revealed that HSRs are involved in protein folding, chaperone activities, and endoplasmic reticulum stress. A nomogram developed from HSR expression profiles demonstrated high accuracy in predicting OA risk. Clustering analysis identified two distinct HSR-related subgroups with unique gene expression and immune profiles. Variations in immune cell infiltration and immune pathway activities were observed between these subgroups. Overall, the study underscores the significance of HSRs in OA pathogenesis and suggests potential personalized therapeutic strategies based on distinct HSR-related subgroups.
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