ArticleBMC cancer2025
Risk of cancer among adult solid organ transplant recipients in Quebec, Canada: 1997-2016.
Article in BMC cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Carcinogenic Medications: A Review of Specific Agents and Molecular Mechanisms of Carcinogenesis.Cancer reports (Hoboken, N.J.) · 2026Review
- Skin Cancers in People Living with Human Immunodeficiency Virus (HIV) Infection.Journal of clinical medicine · 2025Article
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
importanceSolid organ transplant (SOT) recipients have a 2-3 times higher cancer risk due to immunosuppressive therapy used for organ rejection, but Canadian data are limited. Understanding cancer incidence in this population is crucial for improving screening and preventive strategies.
objectiveTo estimate cancer incidence among Quebec SOT recipients and compare their risk with that of the general population. SETTING AND
designWe linked two provincial administrative databases from 1997 to 2016 to conduct a retrospective cohort study. Cancer incidence rates were stratified by sex and age, and standardized risk ratios and 95% confidence intervals were calculated by comparing the observed cancer cases in our study population to the expected cases in the general population using the Quebec cancer registry.
participantsA total of 6,873 transplant recipients, including 4,284 kidney, 1,142 liver, 612 heart, 443 lung, and 392 other/multiple transplant recipients. MAIN OUTCOME AND MEASURES: The primary outcome of interest was cancer incidence. Cancer incidence rates were calculated per 1,000 person-years. The standardized risk ratio (SRR) was used to quantify cancer risk relative to the general population.
resultsAmong 6,873 transplant recipients, 1,142 developed cancers, yielding an incidence rate of 23.5 per 1000 person-years (95% CI: 22.1-24.9). Skin cancer was the most common, followed by lymphoid, hematopoietic, and digestive cancers. The overall SRR showed a 2.6-fold higher cancer risk than in the general population. CONCLUSION AND RELEVANCE: Solid organ transplant recipients in Quebec face a higher cancer risk than the general population. A nationwide study is needed to inform health policies and improve management of this vulnerable population.
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