ArticleJournal of assisted reproduction and genetics2025
Loss of FUT8 impairs embryonic development by reducing cAMP production in granulosa cells.
Article in Journal of assisted reproduction and genetics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
purposeIn cases of impaired fertility, the quality of oocytes and their subsequent embryonic development following fertilization are critical concerns in clinical practice. Core fucosylation, catalyzed by fucosyltransferase 8 (FUT8), is a common N-glycosylation modification that plays a key role in cell proliferation and signal transduction. This study examines the role of core fucosylation in follicular regulation during oocyte development.
methodsPatients were categorized into two groups based on their embryo formation rates. Core fucosylation levels, catalyzed by FUT8, were assessed in serum and follicular fluid (containing granulosa cells). To investigate the molecular effects of FUT8 on oocyte quality, FUT8-knockdown human granulosa cells (KGN-KD), and ovaries from Fut8 gene knockout (Fut8
resultsCore fucosylation levels were lower in patients with reduced blastocyst formation rates. FUT8 depletion led to decreased cAMP production following follicle-stimulating hormone (FSH) stimulation in both KGN-KD and the ovaries of Fut8
conclusionThese findings indicate that FUT8 ablation may disrupt embryonic development post-fertilization by reducing FSH receptor (FSHR) signaling and downregulating FIGLA expression. The results suggest that core fucosylation is essential for female reproduction and oocyte quality.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.