Evidence map›Paper›PMID 40473807›Full record

ReviewPediatric research2026

The role of NLRP3 inflammasome in necrotizing enterocolitis.

Xiuhui Chen, Rui Long, Fengdan Xu, Weijun Ye, Ning Li

Abstract readReview
PubMed Publisher
In one paragraph

Review in Pediatric research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Xiuhui Chen *Dongguan Children's Hospital Affiliated to Guangdong Medical University, The Eighth People's Hospital of Dongguan, Dongguan, 523000, China.
Rui Long *Dongguan Children's Hospital Affiliated to Guangdong Medical University, The Eighth People's Hospital of Dongguan, Dongguan, 523000, China.
Fengdan XuDongguan Children's Hospital Affiliated to Guangdong Medical University, The Eighth People's Hospital of Dongguan, Dongguan, 523000, China.
Weijun YeDongguan Children's Hospital Affiliated to Guangdong Medical University, The Eighth People's Hospital of Dongguan, Dongguan, 523000, China. yeweijun@ba-hospital.com.
Ning LiDongguan Children's Hospital Affiliated to Guangdong Medical University, The Eighth People's Hospital of Dongguan, Dongguan, 523000, China. ln_progress@163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This review explores the association between the NOD-like receptor pyrin domain-containing protein 3 (NLRP3) inflammasomes and necrotizing enterocolitis (NEC) in neonates. It underscores the role of NLRP3 inflammasome overactivation in NEC pathogenesis and proposes that inhibiting NLRP3 inflammasome activation may improve therapeutic benefits. This review examines various strategies to inhibit NLRP3 inflammasome activation, detailing their pharmacological mechanisms. IMPACT: The aim of this review is to discuss the role of NLRP3 inflammasome in the progression of NEC. Abnormal NLRP3 inflammasome activation in patients with NEC and experimental models. Molecules and proteins have been identified as regulators of NLRP3 inflammasome activity, offering avenues for NEC treatment. The NLRP3 inflammasome is a key contributor to NEC. Novel NLRP3 inflammasome inhibitors are the focus of the development of NEC therapeutics.

Indexed as

Enterocolitis, NecrotizingInflammasomesNLR Family, Pyrin Domain-Containing 3 ProteinAnimalsHumansInfant, NewbornInflammasomesNLR Family, Pyrin Domain-Containing 3 ProteinNLRP3 protein, human

Identifiers

PMID40473807

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.