ArticleScientific reports2025
Exploring the link between osteosarcopenia and osteoarthritis in prediabetic adults using NHANES data.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Systemic implications of osteoarthritis: from local degeneration to systemic metabolic Dysregulation.Journal of translational medicine · 2026Review
- Effect of ultrasound-guided small needle knife on patients with knee osteoarthritis: a randomized clinical trial.Frontiers in medicine · 2026Article
- Machine learning prediction of osteoarthritis risk from volatile organic compound exposure using SHAP interpretation in US adults.Scientific reports · 2025Article
- Association between oxidative balance score and osteosarcopenia in US adults: insights from a population-based study.Frontiers in nutrition · 2025Article
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Authors and funding
9 authors.
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Abstract
This study aims to investigate the impact of sarcopenia, osteopenia, and osteosarcopenia on the risk of developing osteoarthritis (OA) in individuals with prediabetes. We collected and analyzed data from five National Health and Nutrition Examination Surveys (NHANES) conducted between 2001 to 2006, 2013 to 2014, and 2017 to 2018. The study population consisted of participants who self-reported having OA and those who had bone mineral density and skeletal muscle mass index (SMI) measured using dual-energy X-ray absorptiometry (DXA). We employed weighted multinomial logistic regression models and restricted cubic splines to examine the relationship between osteosarcopenia and the risk of OA in prediabetic individuals. Individuals with prediabetes exhibited a greater susceptibility to osteosarcopenia compared to those with normal glucose tolerance (NGT). In adults with prediabetes, muscle mass index (SMI) was independently associated with bone mineral density (BMD). Furthermore, both sarcopenia and osteopenia were positively correlated with osteoarthritis (OA) within the prediabetic population. Notably, the presence of osteosarcopenia in prediabetes significantly increased the risk of developing OA compared to the presence of either sarcopenia or osteopenia alone. In adults with prediabetes, osteopenia and sarcopenia are risk factors for OA, and the combination of sarcopenia and osteopenia further increases the prevalence of OA.
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