Evidence map›Paper›PMID 40473712›Full record

ArticleScientific reports2025

Population screening of adults identifies novel genetic variants associated with celiac disease.

Mohammad Sayeef Alam, Laurent Thomas, Ben Brumpton, Kristian Hveem, Knut E A Lundin, Sebo Withoff, Iris H Jonkers, Ludvig M Sollid, Rebecka Hjort, Eivind Ness-Jensen

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Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Mohammad Sayeef AlamHUNT Center for Molecular and Clinical Epidemiology, NTNU, Norwegian University of Science and Technology, Trondheim, Norway. mohammad.s.alam@ntnu.no.
Laurent ThomasHUNT Center for Molecular and Clinical Epidemiology, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.
Ben BrumptonHUNT Center for Molecular and Clinical Epidemiology, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.
Kristian HveemHUNT Center for Molecular and Clinical Epidemiology, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.
Knut E A LundinDepartment of Gastroenterology, Oslo University Hospital-Rikshospitalet, Oslo, Norway.
Sebo WithoffDepartment of Genetics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Iris H JonkersDepartment of Genetics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Ludvig M SollidNorwegian Coeliac Disease Research Centre, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
Rebecka HjortHUNT Center for Molecular and Clinical Epidemiology, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.
Eivind Ness-JensenHUNT Center for Molecular and Clinical Epidemiology, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Celiac disease (CeD) is an autoimmune disease driven by a complex genetic interplay within and beyond the human leukocyte antigen (HLA) region. Despite this, half of its heritability remains unexplained, with most of the unidentified variants located in non-protein coding regions. Here we performed a genome-wide association study among 52,342 adults screened for CeD, including 465 previously undiagnosed and 361 already diagnosed cases, which mitigated the likely disease misclassification present in previous studies. Genotyping and imputation yielded approximately 24.9 million variants for analysis. The study identified 15 novel associations (P < 5E-08) in 12 loci in addition to all the previously associated loci at lower significance thresholds (P < 5E-03). The 5p15.33 locus in the long non-coding RNA gene (LINC01019) showed the highest potential for a true association with CeD. Notably, variants in 5p15.33 has also been associated with rheumatoid arthritis, suggesting a new shared autoimmune locus.

Indexed as

Celiac DiseaseGenetic Predisposition to DiseaseAdultFemaleGenome-Wide Association StudyGenotypeHumansMaleMiddle AgedPolymorphism, Single NucleotideRNA, Long NoncodingRNA, Long NoncodingAutoimmuneCeliacGlutenGWASNon-HLA

Identifiers

PMID40473712
PMCPMC12141474

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.