Evidence map›Paper›PMID 40473700›Full record

ArticleNPJ vaccines2025

Role of malaria exposure and off-target responses on RTS,S/AS02

Elisa Fuentes, Chenjerai Jairoce, Didac Macià, Leonie Mayer, Jorge P Torres-Yaguana, Marta Vidal, Rebeca Santano, David L Narum, David Cavanagh, Benoit Gamain and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NPJ vaccines, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Trial
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Elisa FuentesISGlobal, Barcelona, Spain.
Chenjerai JairoceISGlobal, Barcelona, Spain.
Didac MaciàISGlobal, Barcelona, Spain.
Leonie MayerISGlobal, Barcelona, Spain.
Jorge P Torres-YaguanaISGlobal, Barcelona, Spain.
Marta VidalISGlobal, Barcelona, Spain.
Rebeca SantanoISGlobal, Barcelona, Spain.
David L NarumLaboratory of Malaria Immunology and Vaccinology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
David CavanaghInstitute of Immunology & Infection Research and Centre for Immunity, Infection & Evolution, Ashworth Laboratories, School of Biological Sciences, University of Edinburgh, King's Buildings, Edinburgh, UK.
Benoit GamainSorbonne Université, CNRS, Inserm, Centre d'Immunologie et des Maladies Infectieuses, CIMI, Paris, France.
Ross L CoppelInfection and Immunity Program, Monash Biomedicine Discovery Institute and Department of Microbiology, Monash University, Melbourne, VIC, Australia.
James G BeesonMacfarlane Burnet Institute for Medical Research and Public Health, Melbourne, VIC, Australia.
Sheetij DuttaU.S. Military Malaria Vaccine Program, Walter Reed Army Institute of Research (WRAIR), Silver Spring, Maryland, USA.
Jahit SacarlalCentro de Investigação em Saúde de Manhiça, Maputo, Mozambique.
Ruth AguilarISGlobal, Barcelona, Spain.
Gemma MoncunillISGlobal, Barcelona, Spain. gemma.moncunill@isglobal.org.
Carlota DobañoISGlobal, Barcelona, Spain. carlota.dobano@isglobal.org.

Funding

Baseline host and environmental factors that impact pre-erythrocytic malaria vaccine (hypo)responsiveness in endemic regionsU01AI165745 · NIAID · LEIDEN UNIVERSITY MEDICAL CENTER · PI Maria Yazdanbakhsh · 2022 to 2026
$3.3M
Understanding RTS,S malaria vaccine-induced protection through integrated analysiR01AI095789 · NIAID · BARCELONA INTERNATIONAL HEALTH RES CTR · PI DOBANO, CARLOTA · 2012 to 2016
$3.2M
Agència de Gestió d'Ajuts Universitaris i de Recerca 2019 FI_B 00986Ministerio de Ciencia e Innovación 2020-029886-I/AEI/10.13039/501100011033Ministerio de Ciencia, Innovación y Universidades PI11/00423 and PI17/02044National Institute of Allergy and Infectious Diseases R01AI095789, U01AI165745NIAID NIH HHS R01 AI095789NIAID NIH HHS U01 AI165745
6 · The paper itself

Abstract

RTS,S/AS01

Identifiers

PMID40473700
PMCPMC12141681

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.