ArticleCell death & disease2025
Circular RNA TFRC/SCD1 mRNA interaction regulates ferroptosis and metastasis in gastric cancer.
Article in Cell death & disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- The pivotal role of SCD1 in digestive cancers: Bridging lipid metabolic reprogramming and programmed cell death (Review).International journal of oncology · 2026Review
- m6A-methylated circFANCB Promotes Gastric Cancer Progression by Regulating Cellular Ferroptosis Through miR-454-3p/CEACAM5.Journal of biochemical and molecular toxicology · 2026Article
- TRAPPC4 Promotes GPX4 Stability to Drive Ferroptosis Resistance and Tumor Progression in Head and Neck Squamous Cell Carcinoma.Cancer research · 2026Article
- Metabolic remodeling by circular RNAs in gastric tumorigenesis: From mechanisms to biomarker discovery (Review).International journal of oncology · 2026Review
- Exosomal circ0000549 promotes MNNG‑induced gastric cancer through miR‑15b‑5p/KIF1B.International journal of molecular medicine · 2026Article
- hsa_circ_0068631 facilitates the progression of diabetic retinopathy via regulating miR-140-5p in retinal microvascular endothelial cells.BMC ophthalmology · 2026Article
- Exploring 14-3-3ζ: insights into its role in cancer mechanisms and future therapeutic applications.Hereditas · 2026Review
- Review
- Ferroptosis and metastasis: molecular checkpoints, microenvironmental dynamics, and therapeutic opportunities.Molecular cancer · 2026Review
- Silencing of circRERE(4-5) inhibits ONECUT2-mediated tumorigenesis and metastasis in gastric cancer.Frontiers in immunology · 2026Article
- Circular RNA circAHSA1 serves as a stable serum biomarker for the diagnosis and progression of gastric cancer.Translational oncology · 2026Article
- Transferrin receptor serves a role in promoting PANoptosis in thyroid cancer.Oncology letters · 2026Article
- CircATP2C1 Drives Prostate Cancer Progression Through miR-654-3p-Mediated SLC7A11 Upregulation and Ferroptosis Suppression.Cancers · 2025Article
- Upregulated Circular RNAs in Gastric Cancer: Target Identification and Tools for Therapeutic Intervention.Cancer genomics & proteomicsReview
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
Ferroptosis, an iron-dependent form of programmed cell death, holds promise for cancer treatment. Circular RNAs (circRNAs), widely expressed across tumor types, modulate multiple cellular biological processes, including ferroptosis. However, the regulatory dynamics of circRNAs in gastric cancer (GC)-associated ferroptosis remain poorly understood. Here, circTFRC (circBase ID: hsa_circ_0068606), a novel circRNA, was identified as significantly upregulated in GC tissues and cell lines, with its plasma levels strongly associated with tumor size and metastatic status. Targeted suppression of circTFRC enhanced ferroptotic cell death, resulting in reduced proliferation and motility of GC cells in vitro. At the molecular level, circTFRC bound directly to SCD1 mRNAs, stabilizing and enhancing their translation via recruiting the RNA-binding protein ELAVL1. Elevated SCD1 expression mitigated ferroptosis and promoted oncogenic lipid metabolic reprogramming, thereby driving GC progression. In vivo studies further confirmed that circTFRC silencing promoted ferroptosis and inhibited tumor growth and progression. These results delineate a circTFRC-mediated axis that impairs ferroptosis vulnerability in GC cells and supports malignancy advancement. CircTFRC emerges as a biomarker with diagnostic potential and a candidate for therapeutic intervention targeting ferroptosis in GC.
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