Evidence map›Paper›PMID 40473473›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2025

Salience Signaling and Stimulus Scaling of Ventral Tegmental Area Glutamate Neuron Subtypes.

Dillon J McGovern, Alysabeth Phillips, Annie Ly, Emily D Prévost, Lucy Ward, Kayla Siletti, Yoon Seok Kim, Lief E Fenno, Charu Ramakrishnan, Karl Deisseroth and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Untangling dopamine and glutamate in the ventral tegmental area.bioRxiv : the preprint server for biology · 2025
    Article
  6. Monosynaptic Inputs to Ventral Tegmental Area Glutamate and GABA Co-transmitting Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Dillon J McGovernDepartment of Psychology and Neuroscience, University of Colorado Boulder, Boulder, Colorado 80301.
Alysabeth PhillipsDepartment of Psychology and Neuroscience, University of Colorado Boulder, Boulder, Colorado 80301.
Annie LyDepartment of Psychology and Neuroscience, University of Colorado Boulder, Boulder, Colorado 80301.
Emily D PrévostDepartment of Psychology and Neuroscience, University of Colorado Boulder, Boulder, Colorado 80301.
Lucy WardDepartment of Psychology and Neuroscience, University of Colorado Boulder, Boulder, Colorado 80301.
Kayla SilettiDepartment of Psychology and Neuroscience, University of Colorado Boulder, Boulder, Colorado 80301.
Yoon Seok KimDepartment of Psychiatry and Behavioral Sciences, Stanford University, Stanford, California 94305.
Lief E FennoDepartment of Psychiatry and Behavioral Sciences, Stanford University, Stanford, California 94305.
Charu RamakrishnanDepartment of Bioengineering, Stanford University, Stanford, California 94305.ORCID 0000-0002-3474-6332
Karl DeisserothDepartment of Psychiatry and Behavioral Sciences, Stanford University, Stanford, California 94305.
Michael V BarattaDepartment of Psychology and Neuroscience, University of Colorado Boulder, Boulder, Colorado 80301.
Christopher P FordDepartment of Pharmacology, University of Colorado School of Medicine, Anschutz Medical Campus, Aurora, Colorado 80045.ORCID 0000-0002-4175-2933
David H RootDepartment of Psychology and Neuroscience, University of Colorado Boulder, Boulder, Colorado 80301 david.root@colorado.edu.ORCID 0000-0002-1927-2175

Funding

Encoding Dopamine Signals in the Mesolimbic SystemR01DA035821 · NIDA · UNIVERSITY OF COLORADO DENVER · PI FORD, CHRISTOPHER PETER · 2013 to 2023
$3.5M
Genetic dissection of ventral tegmental area glutamate and GABA neurons in reward and aversionR01DA047443 · NIDA · UNIVERSITY OF COLORADO · PI ROOT, DAVID H · 2020 to 2024
$1.7M
BNST circuitry to hypothalamic regions in stress-induced avoidanceF31MH132322 · NIMH · UNIVERSITY OF COLORADO · PI LY, ANNIE · 2023 to 2024
$82k
Balancing excitatory and inhibitory LHb signaling underlying stressF31MH125569 · NIMH · UNIVERSITY OF COLORADO · PI MCGOVERN, DILLON · 2021 to 2022
$78k
NIDA NIH HHS R01 DA035821NIDA NIH HHS R01 DA047443NIMH NIH HHS F31 MH125569NIMH NIH HHS F31 MH132322
6 · The paper itself

Abstract

Ventral tegmental area (VTA) glutamatergic neurons participate in reward, aversion, drug-seeking, and stress. Subsets of these neurons cotransmit glutamate and GABA (VGluT2

Indexed as

Glutamic AcidNeuronsRewardSignal TransductionVentral Tegmental AreaAnimalsFemaleMaleMiceMice, Inbred C57BLMice, TransgenicSucroseVesicular Glutamate Transport Protein 2Vesicular Inhibitory Amino Acid Transport ProteinsGlutamic AcidSlc17a6 protein, mouseSucroseVesicular Glutamate Transport Protein 2Vesicular Inhibitory Amino Acid Transport Proteinsaversiondopaminerewardsaliencetransmission

Identifiers

PMID40473473
PMCPMC12225595

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.