Evidence map›Paper›PMID 40473425›Full record

ArticleAJNR. American journal of neuroradiology2025

CSF-Venous Fistula Transvenous Onyx Embolization: Evaluation of Onyx Migration into the CSF and Potential One-Way Physiology.

Charlotte Michaelcheck, Waleed Brinjikji, Ajay A Madhavan, John Benson, Jared Verdoorn, Ben Johnson-Tesch, Jeremy Cutsforth-Gregory, Ian T Mark

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In one paragraph

Article in AJNR. American journal of neuroradiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Charlotte MichaelcheckFrom the Department of Radiology (C.M., W.B., A.A.M., J.B., J.V., B.J.-T., I.T.M.), Mayo Clinic, Rochester, Minnesota.
Waleed BrinjikjiFrom the Department of Radiology (C.M., W.B., A.A.M., J.B., J.V., B.J.-T., I.T.M.), Mayo Clinic, Rochester, Minnesota.ORCID https://orcid.org/0000-0001-5271-5524
Ajay A MadhavanFrom the Department of Radiology (C.M., W.B., A.A.M., J.B., J.V., B.J.-T., I.T.M.), Mayo Clinic, Rochester, Minnesota.ORCID https://orcid.org/0000-0003-1794-4502
John BensonFrom the Department of Radiology (C.M., W.B., A.A.M., J.B., J.V., B.J.-T., I.T.M.), Mayo Clinic, Rochester, Minnesota.ORCID https://orcid.org/0000-0002-4038-5422
Jared VerdoornFrom the Department of Radiology (C.M., W.B., A.A.M., J.B., J.V., B.J.-T., I.T.M.), Mayo Clinic, Rochester, Minnesota.ORCID https://orcid.org/0000-0002-1592-1182
Ben Johnson-TeschFrom the Department of Radiology (C.M., W.B., A.A.M., J.B., J.V., B.J.-T., I.T.M.), Mayo Clinic, Rochester, Minnesota.
Jeremy Cutsforth-GregoryDepartment of Neurology (J.C.-G.), Mayo Clinic, Rochester, Minnesota.ORCID https://orcid.org/0000-0002-5689-4424
Ian T MarkFrom the Department of Radiology (C.M., W.B., A.A.M., J.B., J.V., B.J.-T., I.T.M.), Mayo Clinic, Rochester, Minnesota Mark.Ian@mayo.edu.ORCID https://orcid.org/0000-0002-4036-2992

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

background and purposeCSF-venous fistulas (CVFs) are abnormal connections between the subarachnoid space and a paraspinal vein. Transvenous Onyx embolization is a recently adopted treatment method for CVF closure, however no studies have specifically evaluated for Onyx migration into the CSF. The purpose of our study was to evaluate patients who underwent transvenous CVF embolization for Onyx migration into the CSF. MATERIALS AND

methodsWe evaluated 100 patients who underwent transvenous CVF embolization with posttreatment CT of the spine. Images were reviewed for Onyx migration into the CSF at the level of the embolization as well as distally in the lumbar spine. Basic demographic information including age and sex were recorded.

resultsThe mean age was 59.2 years (±10.9, 28-88). Sixty-eight patients were women. Forty-eight patients had postembolization imaging of the treated level, and none had Onyx migration into the CSF at the level of the CVF. Thirty-four patients had imaging of the lumbar spine, and none had Onyx migration distally in the lumbar spine.

conclusionsOur study did not find any cases of unintended Onyx migration into the subarachnoid space in patients who underwent transvenous CVF embolization. This speaks to the safety profile of transvenous CVF embolization and suggests possible one-way physiology of CVF that allows for egress from the CSF to the veins only.

Indexed as

Dimethyl SulfoxideEmbolization, TherapeuticForeign-Body MigrationPolyvinylsAdultAgedAged, 80 and overFemaleHumansMaleMiddle AgedRetrospective StudiesTreatment OutcomeDimethyl SulfoxideOnyx copolymerPolyvinyls

Identifiers

PMID40473425
PMCPMC12453486

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.