Evidence map›Paper›PMID 40473413›Full record

Trial reportThorax2025

Optimised oxygenation improves functional capacity during daily activities in patients with COPD on long-term oxygen therapy: a randomised crossover trial.

Linette Marie Kofod, Ejvind Frausing Hansen, Barbara Christina Brocki, Morten Tange Kristensen, Nassim Bazeghi Roberts, Elisabeth Westerdahl

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Thorax, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05553847 (Automated Oxygen Titration to Improve Activities of Daily Living in Patients With Chronic Obstructive Pulmonary Disease on Home Oxygen), which is not on this map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05553847 nacompletednot on this map

Automated Oxygen Titration to Improve Activities of Daily Living in Patients With Chronic Obstructive Pulmonary Disease on Home Oxygen

TypeinterventionalSponsorHvidovre University HospitalRan2022 to 2023Enrolled32ConditionsCOPD (Chronic Obstructive Pulmonary Disease)ArmsAutomated oxygen titration based on the oxygen saturation during activity
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Article
  4. The future of home oxygen therapy.European respiratory review : an official journal of the European Respiratory Society · 2026
    Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Linette Marie KofodPMR-C, Department of Physio- and Occupational Therapy, Copenhagen University Hospital, Hvidovre, Hvidovre, Denmark linette.marie.kofod@regionh.dk.ORCID 0000-0002-1184-9451
Ejvind Frausing HansenDepartment of Pulmonology, Copenhagen University Hospital, Hvidovre, Hvidovre, Denmark.
Barbara Christina BrockiDepartment of Physiotherapy and Occupational Therapy, Aalborg University Hospital, Aalborg, Denmark.
Morten Tange KristensenDepartment of Physical and Occupational Therapy, Copenhagen University Hospital, Bispebjerg, Copenhagen, Denmark.
Nassim Bazeghi RobertsDepartment of Pulmonology and Infection, Copenhagen University Hospital, Bispebjerg, Copenhagen, Denmark.
Elisabeth WesterdahlUniversity Health Care Research Center, Faculty of Medicine and Health, Örebro University, Örebro, Sweden.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMinimising hypoxaemia during submaximal walking tests has a positive effect on exercise capacity and dyspnoea in patients with chronic obstructive pulmonary disease (COPD) on long-term oxygen therapy (LTOT). However, the impact of optimising oxygenation during everyday tasks remains unexplored. Therefore, we investigated the effects of maintaining a target saturation on activities of daily living (ADL) using automated oxygen titration compared with conventional fixed oxygen flow.

methodsIn a double-blinded, randomised crossover trial, patients with COPD on LTOT performed two GlittreADL tests to assess the functional capacity of everyday activities using (1) their fixed oxygen dose and (2) an adjusted flow from 0 to 8 L/min targeting a peripheral oxygen saturation (SpO

results31 patients (mean±SD age: 72.8±5.9 years, forced expiratory volume in 1 s of % predicted: 36.7±12.7) were included. The patients reduced the time to perform the ADL test by median (IQR) 38 (12-73) s, p<0.001, using automated titration compared with the fixed oxygen flow. The oxygen flow in the automated arm more than tripled to 5.4 (4.1-6.8) versus 1.6 (1.1-2.1) L/min (fixed) during the test, p<0.001, while the time spent within SpO

conclusionsImproving oxygenation and extending the time spent within target saturation reduced dyspnoea and improved functional capacity in ADL in patients with COPD on LTOT. TRIAL REGISTRATION NUMBER: NCT05553847.

Indexed as

Activities of Daily LivingOxygenOxygen Inhalation TherapyPulmonary Disease, Chronic ObstructiveAgedCross-Over StudiesDouble-Blind MethodDyspneaExercise ToleranceFemaleForced Expiratory VolumeHumansMaleMiddle AgedOximetryOxygen SaturationOxygenCOPD PathologyExerciseHypoxemiaLong Term Oxygen Therapy (LTOT)Pulmonary Rehabilitation

Identifiers

PMID40473413
PMCPMC12573330

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.