Observational studyBMJ open respiratory research2025
Predictors of sleep-disordered breathing and chronic hypoventilation in obese women and men: a cross-sectional observational study.
Observational study in BMJ open respiratory research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
2 citing papers in PubMed.
- Nocturnal hypoxemic burden in obesity hypoventilation syndrome compared to obstructive sleep apnea: a case-control study.Sleep & breathing = Schlaf & Atmung · 2026Article
- A Multidisciplinary Approach to Obesity Hypoventilation Syndrome: From Diagnosis to Long-Term Management-A Narrative Review.Diagnostics (Basel, Switzerland) · 2025Review
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
aimObesity is associated with an increased risk of sleep-disordered breathing (SDB)-obstructive sleep apnoea (OSA) and sleep hypoventilation-and obesity hypoventilation syndrome (OHS). The aim was to assess the impact of obesity on lung volumes and the prevalence of SDB and OHS and to identify predictors of these.
methodsIn a cross-sectional analysis, obese patients (body mass index ≥30 kg/m
resultsIn 1065 obese adults (39% female; 48% obesity WHO I, 24% WHO II, 28% WHO III), the prevalence of OSA (apnoea hypopnoea index (AHI) ≥5/hour), severe OSA (AHI ≥30/hour), sleep hypoventilation and OHS was 77%, 29%, 21% and 8%, respectively. The likelihood of OSA, severe OSA and sleep hypoventilation increased with obesity class, while the presence of OHS did not differ between groups. In multivariate regression models including body mass index, neck circumference, age, sex, AHI, bicarbonate and expiratory reserve volume, bicarbonate and forced vital capacity were independent predictors of both sleep hypoventilation and OHS and neck circumference of severe OSA. The area under the receiver operating characteristics curve of bicarbonate for OHS and sleep hypoventilation was 0.92 and 0.72, respectively.
conclusionsThree quarter of obese patients have OSA, and the likelihood of OSA, severe OSA and sleep hypoventilation increase across obesity severity groups. Bicarbonate has a high diagnostic accuracy for OHS.
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