Evidence map›Paper›PMID 40473222›Full record

ArticleToxicon : official journal of the International Society on Toxinology2025

Precise mapping of a snake venom phospholipase A

Ying Jia, Christine Vega, Anthony Hinojosa, Jocelyn Perales

Abstract read
In one paragraph

Article in Toxicon : official journal of the International Society on Toxinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Ying JiaSchool of Integrative Biological and Chemical Sciences, The University of Texas Rio Grande Valley, Brownsville, TX, 78520, USA. Electronic address: ying.jia@utrgv.edu.
Christine VegaSchool of Integrative Biological and Chemical Sciences, The University of Texas Rio Grande Valley, Brownsville, TX, 78520, USA.
Anthony HinojosaSchool of Integrative Biological and Chemical Sciences, The University of Texas Rio Grande Valley, Brownsville, TX, 78520, USA.
Jocelyn PeralesSchool of Integrative Biological and Chemical Sciences, The University of Texas Rio Grande Valley, Brownsville, TX, 78520, USA.

Funding

Identifying the Interactions between Animal Toxins and Human nAChRs: The Role of Snake PLA2 in Interacting with nAChR alpha SubunitsR15NS128563 · NINDS · UNIVERSITY OF TEXAS RIO GRANDE VALLEY · PI JIA, YING · 2022 to 2024
$448k
NINDS NIH HHS R15 NS128563
6 · The paper itself

Abstract

The identification of selective molecules that interact with specific human nicotinic acetylcholine receptor (nAChR) subtypes is essential for elucidating their structure and function. Animal venoms, particularly snake venoms, offer a diverse repertoire of bioactive molecules that may selectively bind to human nAChR subtypes. In this study, we cloned transcripts encoding human nAChR subunits and successfully expressed their extracellular domains (ECDs) in yeast cells. We further examined the interactions between nAChR subunits and snake venom toxins, identifying that snake Asp49-phospholipase A

Indexed as

Phospholipases A2Receptors, NicotinicSnake VenomsAmino Acid SequenceAnimalsBinding SitesHumansProtein BindingPhospholipases A2Receptors, NicotinicSnake VenomsHuman nAChRProtein-protein interactionSnake PLA(2)

Identifiers

PMID40473222
PMCPMC13245273

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.