Evidence map›Paper›PMID 40473021›Full record

ArticleVirologica Sinica2025

The slow progression of Japanese encephalitis in aged mice is likely associated to B cell recruitment in the brain.

Zheng-Ran Song, Yi-Lin Yang, Yang Zhou, Li-Bo Liu, Fei-Yang Xue, Lin-Shen-Yang Liu, Na Gao, Dong-Ying Fan, Yi-Song Wang, Jing An and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Virologica Sinica, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Zheng-Ran SongDepartment of Microbiology, School of Basic Medical Sciences, Capital Medical University, Beijing, 100069, China; Laboratory for Clinical Medicine, Capital Medical University, Beijing, 100069, China.
Yi-Lin YangDepartment of Microbiology, School of Basic Medical Sciences, Capital Medical University, Beijing, 100069, China; Laboratory for Clinical Medicine, Capital Medical University, Beijing, 100069, China.
Yang ZhouDepartment of Microbiology, School of Basic Medical Sciences, Capital Medical University, Beijing, 100069, China; Laboratory for Clinical Medicine, Capital Medical University, Beijing, 100069, China.
Li-Bo LiuDepartment of Parasitology, School of Basic Medical Sciences, Guizhou Medical University, Guiyang, 561113, China.
Fei-Yang XueDepartment of Microbiology, School of Basic Medical Sciences, Capital Medical University, Beijing, 100069, China; Laboratory for Clinical Medicine, Capital Medical University, Beijing, 100069, China.
Lin-Shen-Yang LiuDepartment of Microbiology, School of Basic Medical Sciences, Capital Medical University, Beijing, 100069, China; Laboratory for Clinical Medicine, Capital Medical University, Beijing, 100069, China.
Na GaoDepartment of Microbiology, School of Basic Medical Sciences, Capital Medical University, Beijing, 100069, China; Laboratory for Clinical Medicine, Capital Medical University, Beijing, 100069, China.
Dong-Ying FanDepartment of Microbiology, School of Basic Medical Sciences, Capital Medical University, Beijing, 100069, China; Laboratory for Clinical Medicine, Capital Medical University, Beijing, 100069, China.
Yi-Song WangDepartment of Microbiology, School of Basic Medical Sciences, Capital Medical University, Beijing, 100069, China; Laboratory for Clinical Medicine, Capital Medical University, Beijing, 100069, China. Electronic address: yswang@ccmu.edu.cn.
Jing AnDepartment of Microbiology, School of Basic Medical Sciences, Capital Medical University, Beijing, 100069, China; Laboratory for Clinical Medicine, Capital Medical University, Beijing, 100069, China. Electronic address: anjing@ccmu.edu.cn.
Pei-Gang WangDepartment of Microbiology, School of Basic Medical Sciences, Capital Medical University, Beijing, 100069, China; Laboratory for Clinical Medicine, Capital Medical University, Beijing, 100069, China. Electronic address: pgwang@ccmu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The Japanese encephalitis virus (JEV) causes Japanese encephalitis (JE), a severe disease that primarily affects children and induces significant central nervous system complications. With the widespread adoption of vaccination in children, the incidence among older individuals has increased substantially. Despite this epidemiological shift, research on JEV infection in the elderly remains limited. We established JEV infection models using both aged and young mice to explore age-related differences in pathology and underlying mechanisms. Brain tissue samples were analyzed for pathological changes and viral tropism in major cell types. To further characterize immune response variations, we conducted transcriptomic sequencing on the brain tissues following JEV infection. Aged mice exhibited lower mortality, delayed disease progression, and milder brain pathology compared to young mice after JEV infection. Viral titers and infection rates of major brain cell types were similar in both groups. Transcriptomic analysis revealed diminished immune activation and weaker inflammatory responses in aged mice. Additionally, microglial activation and CD8

Indexed as

B-LymphocytesBrainEncephalitis, JapaneseEncephalitis Virus, JapaneseAge FactorsAgingAnimalsCD8-Positive T-LymphocytesDisease Models, AnimalDisease ProgressionFemaleGene Expression ProfilingMiceMice, Inbred C57BLMicrogliaViral LoadAged miceB cellsInflammationJapanese encephalitis virus (JEV)RNA-seq

Identifiers

PMID40473021
PMCPMC12414395

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.