Evidence map›Paper›PMID 40472999›Full record

ReviewSurvey of ophthalmology

Pathophysiology of intraoperative floppy iris syndrome: An unsettled debate.

Yingchun Shen, Rachel Frauches, Jingyu Zhao, Chien-Hui Lo, Ke Ning, Siyu Chen, Zhiquan Liu, Fan Zhang, Yang Sun

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Survey of ophthalmology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yingchun ShenDepartment of Ophthalmology, Stanford University School of Medicine, Palo Alto, CA 94306, USA.
Rachel FrauchesDepartments of Pathology, Stanford University School of Medicine, Stanford, CA, USA.
Jingyu ZhaoDepartment of Ophthalmology, Stanford University School of Medicine, Palo Alto, CA 94306, USA.
Chien-Hui LoDepartment of Ophthalmology, Stanford University School of Medicine, Palo Alto, CA 94306, USA.
Ke NingDepartment of Ophthalmology, Stanford University School of Medicine, Palo Alto, CA 94306, USA.
Siyu ChenDepartment of Ophthalmology, Stanford University School of Medicine, Palo Alto, CA 94306, USA.
Zhiquan LiuDepartment of Ophthalmology, Stanford University School of Medicine, Palo Alto, CA 94306, USA.
Fan ZhangDepartment of Ophthalmology, Stanford University School of Medicine, Palo Alto, CA 94306, USA.
Yang SunDepartment of Ophthalmology, Stanford University School of Medicine, Palo Alto, CA 94306, USA; VA Palo Alto Healthcare System, Palo Alto, CA, USA. Electronic address: yangsun@stanford.edu.

Funding

The role of primary cilia in glaucoma pathogenesisR01EY025295 · NEI · STANFORD UNIVERSITY · PI Yang Sun · 2016 to 2026
$3.5M
Phosphoinositide signaling in glaucoma: rescue strategies for Lowe syndromeR01EY032159 · NEI · STANFORD UNIVERSITY · PI SUN, YANG · 2021 to 2024
$1.6M
Glaucoma Pathogenesis of Oculocerebrorenal syndrome of LoweK08EY022058 · NEI · STANFORD UNIVERSITY · PI SUN, YANG · 2012 to 2016
$994k
Stanford Ophthalmology Advanced Research ProgramR38EY037090 · NEI · STANFORD UNIVERSITY · PI Yang Sun · 2025 to 2026
$495k
BLRD VA I01 BX006638CSRD VA I01 CX001481NEI NIH HHS K08 EY022058NEI NIH HHS R01 EY025295NEI NIH HHS R01 EY032159NEI NIH HHS R38 EY037090
6 · The paper itself

Abstract

Intraoperative floppy iris syndrome (IFIS)--characterized by iris blowing, prolapse, and progressive miosis during phacoemulsification surgery--poses significant challenges for eye surgeons. Despite being described almost 2 decades ago, its pathophysiology remains unclear. Initially, IFIS was thought to be a result of sympathetic signal blockage in the iris dilator muscle, since α-blockers such as tamsulosin were found to be a strong predisposing factor; however, many IFIS cases occur even in patients who discontinued α-blockers prior to cataract surgery. Several potential mechanisms through which α-blockers induces chronic changes in the iris - iris dilator atrophy, drug-melanin interaction, and loss of vascular tone - have been proposed as possible mechanisms. We address the prevailing theories on α-receptor-dependent mechanisms for IFIS and the current prophylactic measures undertaken to prevent IFIS-associated intraocular complications.

Indexed as

Intraoperative ComplicationsIrisIris DiseasesMiosisPhacoemulsificationAdrenergic alpha-1 Receptor AntagonistsHumansSyndromeAdrenergic alpha-1 Receptor AntagonistsCataractCataract surgery complicationIntraoperative floppy iris syndromePathophysiologyPhacoemulsification

Identifiers

PMID40472999
PMCPMC12414435

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.