Evidence map›Paper›PMID 40472985›Full record

ArticleThe journal of pain2025

Reduced trapezius pressure pain threshold in fibromyalgia and opioid use.

Carina Lei, Su Hyoun Park, Edna J Evington, Morgan A Rosser, Katherine T Martucci

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The journal of pain, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05905419 (Neurobiological Consequences of Long-Term Opioid Therapy in the Brain and Spinal Cord), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05905419 narecruitingnot on this map

Neurobiological Consequences of Long-Term Opioid Therapy in the Brain and Spinal Cord

TypeinterventionalSponsorDuke UniversityRan2023 to 2027Enrolled140ConditionsChronic Pain, Opioid UseArmsOpioid Phase
3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Trial
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Carina LeiHuman Affect and Pain Neuroscience Laboratory, Department of Anesthesiology, Duke University Medical Center, Durham, NC, USA; Center for Translational Pain Medicine, Duke University Medical Center, Durham, NC, USA.
Su Hyoun ParkHuman Affect and Pain Neuroscience Laboratory, Department of Anesthesiology, Duke University Medical Center, Durham, NC, USA; Center for Translational Pain Medicine, Duke University Medical Center, Durham, NC, USA; BK21 FOUR R&E Center for Psychology, Korea University, Seoul, South Korea.
Edna J EvingtonHuman Affect and Pain Neuroscience Laboratory, Department of Anesthesiology, Duke University Medical Center, Durham, NC, USA; Center for Translational Pain Medicine, Duke University Medical Center, Durham, NC, USA.
Morgan A RosserDepartment of Anesthesiology, Biostatistics Group, Duke University School of Medicine, Durham, NC, USA.
Katherine T MartucciHuman Affect and Pain Neuroscience Laboratory, Department of Anesthesiology, Duke University Medical Center, Durham, NC, USA; Center for Translational Pain Medicine, Duke University Medical Center, Durham, NC, USA. Electronic address: katherine.martucci@duke.edu.

Funding

Neurobiological Consequences of Long-Term Opioid Therapy in the Brain and Spinal CordR01DA055850 · NIDA · DUKE UNIVERSITY · PI Katherine Theresa Martucci · 2022 to 2026
$3.2M
The Impact of Opioids on Chronic Pain: Clinical Research and Career Training in Spinal Cord fMRI and Brain Reward SystemsR00DA040154 · NIDA · DUKE UNIVERSITY · PI MARTUCCI, KATHERINE THERESA · 2018 to 2021
$827k
The Impact of Opioids on Chronic Pain: Clinical Research and Career Training in Spinal Cord fMRI and Brain Reward SystemsK99DA040154 · NIDA · STANFORD UNIVERSITY · PI MARTUCCI, KATHERINE THERESA · 2015 to 2017
$350k
NIDA NIH HHS K99 DA040154NIDA NIH HHS R00 DA040154NIDA NIH HHS R01 DA055850
6 · The paper itself

Abstract

While opioid medications are potent analgesics, their usage in chronic pain conditions can paradoxically result in opioid-induced hyperalgesia (i.e., enhanced pain sensitivity). However, among individuals with chronic pain, minimal research has examined the effects of long-term opioid medication on pain sensitivity. To better understand how long-term opioid use impacts pain sensitivity, we measured pressure pain threshold (PPT) of the bilateral trapezius among three cohorts: pain-free controls, individuals with fibromyalgia who were not taking opioids (FMN), and individuals with fibromyalgia who were taking opioids long-term (FMO) (NCT05905419). Across these 3 groups, we also measured depression (BSI-18) and fatigue (PROMIS) to examine their relationships with pain sensitivity. Compared to the control group, dominant-side PPT was significantly reduced in both FMN (p = 0.015) and FMO groups (p = 0.004). However, PPT did not significantly differ between FMO versus FMN groups (p = 0.500). Across the fibromyalgia groups, depression and fatigue were not significantly correlated with PPT. From a co-variate analysis and its associated sensitivity analysis, the results did not change when controlling for age, self-identified race, self-identified ethnicity, and BMI. From an exploratory analysis of the FMO group, individuals who took their last opioid medication dose more recently prior to PPT assessment had higher PPTs (i.e., lower pain sensitivity, p < 0.001). In summary, reduced PPT appears to occur similarly across individuals with fibromyalgia regardless of long-term opioid use status; meanwhile, short-term (i.e., more acute) opioid dose timing- related effects on PPT may occur in individuals with fibromyalgia taking opioids long-term. PERSPECTIVE: Compared to pain-free controls, we identified significantly lower pressure pain threshold (PPT) in individuals with fibromyalgia. When comparing individuals taking opioids versus not, PPT was similar across groups regardless of opioid use status. Among the opioid-taking individuals, we identified potential opioid-related effects of PPT increase with more recent opioid dose.

Indexed as

Analgesics, OpioidChronic PainFibromyalgiaPain ThresholdAdultDepressionFatigueFemaleHumansHyperalgesiaMaleMiddle AgedPressureAnalgesics, OpioidAllodyniaCentral sensitizationChronic painOpiateOpioid-induced hyperalgesia

Identifiers

PMID40472985
PMCPMC12353179

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.