Evidence map›Paper›PMID 40472909›Full record

ArticleNeuroImage2025

Regional variation in cerebral oxygen metabolism during acute severe hypoxia with temporary cognitive impairment.

Daehun Kang, Koji Uchida, Clifton R Haider, Norbert G Campeau, Myung-Ho In, Erin M Gray, Joshua D Trzasko, Kirk M Welker, Jeffrey L Gunter, Matt A Bernstein and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NeuroImage, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Review
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Daehun KangDepartment of Radiology, Mayo Clinic, 200 First St. SW, Rochester, MN 55905, USA. Electronic address: Kang.Daehun@mayo.edu.
Koji UchidaDepartment of Anesthesiology and Perioperative Medicine, Mayo Clinic, 200 First St. SW, Rochester, MN 55905, USA.
Clifton R HaiderDepartment of Physiology and Biomedical Engineering, Mayo Clinic, 200 First St. SW, Rochester, MN 55905, USA.
Norbert G CampeauDepartment of Radiology, Mayo Clinic, 200 First St. SW, Rochester, MN 55905, USA.
Myung-Ho InDepartment of Radiology, Mayo Clinic, 200 First St. SW, Rochester, MN 55905, USA.
Erin M GrayDepartment of Radiology, Mayo Clinic, 200 First St. SW, Rochester, MN 55905, USA.
Joshua D TrzaskoDepartment of Radiology, Mayo Clinic, 200 First St. SW, Rochester, MN 55905, USA.
Kirk M WelkerDepartment of Radiology, Mayo Clinic, 200 First St. SW, Rochester, MN 55905, USA.
Jeffrey L GunterDepartment of Radiology, Mayo Clinic, 200 First St. SW, Rochester, MN 55905, USA.
Matt A BernsteinDepartment of Radiology, Mayo Clinic, 200 First St. SW, Rochester, MN 55905, USA.
Max R TrenerryDepartment of Psychiatry and Psychology, Mayo Clinic, 200 First St. SW, Rochester, MN 55905, USA.
David R HolmesDepartment of Physiology and Biomedical Engineering, Mayo Clinic, 200 First St. SW, Rochester, MN 55905, USA.
Michael J JoynerDepartment of Anesthesiology and Perioperative Medicine, Mayo Clinic, 200 First St. SW, Rochester, MN 55905, USA.
Timothy B CurryDepartment of Anesthesiology and Perioperative Medicine, Mayo Clinic, 200 First St. SW, Rochester, MN 55905, USA.
John HustonDepartment of Radiology, Mayo Clinic, 200 First St. SW, Rochester, MN 55905, USA.
Yunhong ShuDepartment of Radiology, Mayo Clinic, 200 First St. SW, Rochester, MN 55905, USA.

Funding

High-performance compact 3T MRI: Technical optimization for advanced brain imagingU01EB024450 · NIBIB · MAYO CLINIC ROCHESTER · PI BERNSTEIN, MATTHEW A., FOO, THOMAS K · 2017 to 2021
$5.3M
NIBIB NIH HHS U01 EB024450
6 · The paper itself

Abstract

Acute exposure to severe hypoxia impairs cognitive performance, yet the integrated brain mechanisms underlying this temporary decline remain unclear. This study examined regional variations in cerebral oxygen metabolism during acute hypoxia and their relationship to cognitive impairment. Eleven young, healthy participants (26.5 ± 4.5 years old) performed the Go/No-Go task during two sessions, each of which includes three minutes of hypoxia (FiO

Indexed as

BrainCerebrovascular CirculationCognitive DysfunctionHypoxiaOxygenOxygen ConsumptionAdultFemaleHumansMagnetic Resonance ImagingMaleYoung AdultOxygenAcute severe hypoxiaBlood oxygenation level dependent contrastCerebral oxygen metabolismCognitive impairmentDavis modelFunctional MRIPerfusion imaging

Identifiers

PMID40472909
PMCPMC13244499

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.