Evidence map›Paper›PMID 40472830›Full record

SynthesisCerebrovascular diseases (Basel, Switzerland)2026

Underreporting of Sex-Specific Findings in Risk Factors for Unruptured Intracranial Aneurysms.

Maaike J A van Eldik, Mariam Ali, Stijn Rietkerken, Sanne A E Peters, Hester M den Ruijter, Ynte M Ruigrok

Abstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Cerebrovascular diseases (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Maaike J A van EldikDepartment of Neurology and Neurosurgery, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands, m.j.a.vaneldik-3@umcutrecht.nl.
Mariam AliDepartment of Neurology, Leiden University Medical Center, Leiden, The Netherlands.
Stijn RietkerkenDepartment of Neurology and Neurosurgery, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
Sanne A E PetersJulius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
Hester M den RuijterLaboratory of Experimental Cardiology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
Ynte M RuigrokDepartment of Neurology and Neurosurgery, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

<p>Introduction: Women are overrepresented in the unruptured intracranial aneurysm (UIA) population, with an overall two-thirds of patients being female. The reasons behind this female preponderance are still unclear. Therefore, we performed a systematic review of clinical risk factors for UIA, with a specific aim of assessing whether these risk factor associations are sex-dependent.

methodsWe systematically searched 5 electronic medical databases for all relevant literature up to March 2024. Cohort and case-control studies reporting on the lifestyle factors smoking, alcohol use, hypertension, hypercholesterolemia, physical activity, diabetes, and BMI were included.

resultsWe found a total of 21 studies, reporting on 347,907 participants and 8,698 UIA cases, that met our inclusion criteria. However, only one study provided its results stratified by sex, making it impossible to perform sex-stratified analyses.

conclusionOur findings illustrate the scarcity of sex-stratified results in studies on risk factors for UIAs. Since knowledge on potential sex differences in UIA could help understand the female predominance, we highlight a need for more sex-stratified research in this field. </p>.

Indexed as

Health Status DisparitiesIntracranial AneurysmAdultAgedFemaleHumansMaleMiddle AgedRisk AssessmentRisk FactorsSex DistributionSex FactorsRisk factorsSex differencesUnruptured intracranial aneurysms

Identifiers

PMID40472830
PMCPMC12233983

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.