Evidence map›Paper›PMID 40472668›Full record

Trial reportVaccine2025

Hesitancy and confidence in pediatric COVID-19 vaccination among diverse caregivers of unvaccinated children.

Lisa M Costello, Ellen K Kerns, Russell J McCulloh, James R Roberts, Daniel B Blatt, Susanne E Tanski, Timothy Ryan Smith, Walter Dehority, Margaret P Huntwork, Zain Alamarat and 7 more

Erratum issuedAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Vaccine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors.

Lisa M CostelloWest Virginia University School of Medicine, Morgantown, WV, United States of America. Electronic address: lmcostello@hsc.wvu.edu.
Ellen K KernsUniversity of Nebraska Medical Center, Omaha, NE, United States of America.
Russell J McCullohUniversity of Nebraska Medical Center, Omaha, NE, United States of America.
James R RobertsMedical University of South Carolina, Charleston, SC, United States of America.
Daniel B BlattNorton Children's Hospital and University of Louisville School of Medicine, Louisville, KY, United States of America.
Susanne E TanskiGeisel School of Medicine at Dartmouth, Hanover, NH, United States of America.
Timothy Ryan SmithUniversity of Kansas Medical Center, Kansas City, KS, United States of America.
Walter DehorityVanderbilt University School of Medicine, Nashville, TN, United States of America.
Margaret P HuntworkTulane University, New Orleans, LA, United States of America.
Zain AlamaratUniversity of Arkansas for Medical Sciences, Little Rock, AR, United States of America.
Melinda D DelaneyWarren Alpert Medical School of Brown University, Providence, RI, United States of America.
Christine W HockettAvera Research Institute, Rapid City, SD, United States of America; Department of Pediatrics, University of South Dakota School of Medicine, Sioux Falls, SD, United States of America.
Ryan S McKeeUniversity of Oklahoma Health Sciences Center, Oklahoma City, OK, United States of America.
Jonathan M MillerNemours Children's Health, Wilmington, DE, United States of America.
Di ChangUniveristy of Arkansas for Medical Sciences, Little Rock, AR, United States of America.
Songthip OunpraseuthUniveristy of Arkansas for Medical Sciences, Little Rock, AR, United States of America.
Sophia R NewcomerUniversity of Montana Center for Population Health Research, Missoula, MT, United States of America.

Funding

Data Coordinating and Operations Center for the ECHO IDeA States Pediatric Clinical Trials NetworkU24OD024957 · OD · UNIV OF ARKANSAS FOR MED SCIS · PI COURTNEY, SHERRY, OUNPRASEUTH, SONGTHIP T. · 2016 to 2024
$80.8M
Sunflower Pediatric Clinical Trials (SPeCTr 3.0)UG1OD024943 · OD · UNIVERSITY OF KANSAS MEDICAL CENTER · PI Ann M Davis, BRIDGETTE L. JONES · 2016 to 2026
$4.7M
Rhode Island Child Clinical Trials CollaborativeUG1OD024951 · OD · RHODE ISLAND HOSPITAL · PI THOMAS H CHUN, PHYLLIS A. DENNERY · 2016 to 2026
$4.7M
UNM Pediatric Clinical Trial Sites in IDeA State Pediatric Clinical Trial NetworkUG1OD024947 · OD · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI Jessie R. Maxwell, Hengameh H Raissy · 2016 to 2026
$4.6M
ISPCTN Pediatric Clinical Trials UnitUG1OD024946 · OD · DARTMOUTH-HITCHCOCK CLINIC · PI Tyler Hartman, Paul E. Palumbo · 2016 to 2026
$4.6M
The DE Nemours/duPont Hospital for Children IDeA States Pediatric Clinical Trials Network SiteUG1OD024958 · OD · NEMOURS CHILDREN'S HOSPITAL, DELAWARE · PI Robert E Akins, Thao-Ly Tam Phan-Vo · 2016 to 2026
$4.5M
Montana Pediatric Clinical Trials SiteUG1OD024952 · OD · UNIVERSITY OF MONTANA · PI Emily Hall, Erin O'Brien Semmens · 2016 to 2026
$4.4M
The Nebraska Pediatric Clinic Trials UnitUG1OD024953 · OD · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI Bradford A Brabec, Ellen Kerns · 2016 to 2026
$4.4M
Trials and ReseArch Network FOR even More- South Carolina (TRANSFORM-3)UG1OD024956 · OD · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI ANDREW M ATZ, Lisa Knight · 2016 to 2026
$4.3M
The Kentucky Pediatric Clinical Trials Rural/Urban PartnershipUG1OD024954 · OD · UNIVERSITY OF LOUISVILLE · PI Lori Ann Devlin-Phinney, Sara E Watson · 2016 to 2026
$4.3M
Arkansas ECHO ISPCTN Site (AREIS)UG1OD024945 · OD · ARKANSAS CHILDREN'S HOSPITAL RES INST · PI Stacie M Jones, Tamara Taylor Perry · 2016 to 2026
$4.3M
The Oklahoma Pediatric Clinical Trials NetworkUG1OD024950 · OD · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI Amanda L Bogie, Jeanie Beatrice Tryggestad · 2016 to 2026
$4.1M
NIH HHS U24 OD024957NIH HHS UG1 OD024943NIH HHS UG1 OD024945NIH HHS UG1 OD024946NIH HHS UG1 OD024947NIH HHS UG1 OD024950NIH HHS UG1 OD024951NIH HHS UG1 OD024952NIH HHS UG1 OD024953NIH HHS UG1 OD024954NIH HHS UG1 OD024956NIH HHS UG1 OD024958NIH HHS UG1 OD024959NIH HHS UG1 OD030016NIH HHS UG1 OD030019
6 · The paper itself

Abstract

introductionUnderstanding factors associated with hesitancy about pediatric COVID-19 vaccination is important for identifying strategies to improve vaccination rates. Our objective was to describe beliefs about COVID-19 vaccination among caregivers who had not yet vaccinated their children against COVID-19.

methodsFrom July 2022 to February 2023, caregivers of children unvaccinated for COVID-19 across 15 states within the IDeA States Pediatrics Clinical Trial Network were recruited into a randomized, controlled trial of a COVID-19 vaccine communication phone app. Recruitment sites served high numbers of children from rural areas or of backgrounds other than non-Hispanic White. At baseline, caregivers answered questions from the SAGE Vaccine Hesitancy Scale (VHS), and questions about trusted sources of information about COVID-19. We compared responses by rurality, race, and ethnicity using chi-square tests, and used multivariable modeling of a composite outcome of summed VHS scores to identify factors associated with vaccine hesitancy.

resultsA total of 725 caregivers were randomized; 512 completed the baseline survey. Many caregivers lived in a rural area (34.9 %) and nearly half were of non-White race (47.3 %). Over 80 % somewhat or strongly agreed that vaccines are important, that childhood vaccines are effective, and that vaccination is a good way to protect children from disease. Rural caregivers were more likely than non-rural caregivers to state that they generally do what their doctor recommends with regard to childhood vaccines (46.93 % vs. 37.00 %, p < .0021). In the multivariable model, the combined group of Asian, Native Hawaiian, Other Pacific Islander or multiracial caregivers, and Black or African American caregivers, had a higher vaccine hesitancy compared to White caregivers (25.25, 25.91, 22.50 respectively) (p < .0001).

conclusionsAs we navigate work to build vaccine confidence, this study provides support for additional directions of study to better understand particular populations and could be further reproduced to look at intentions with other vaccines.

Indexed as

CaregiversCOVID-19COVID-19 VaccinesVaccinationVaccination HesitancyAdolescentAdultChildChild, PreschoolEthnicityFemaleHealth Knowledge, Attitudes, PracticeHumansInfantMaleMiddle AgedCOVID-19 VaccinesCOVID-19 vaccinesPediatricsRural health

Identifiers

PMID40472668
PMCPMC13160452

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.