Evidence map›Paper›PMID 40472644›Full record

SynthesisSocial science & medicine (1982)2025

Area-level socioeconomic status is associated with colorectal cancer screening, incidence and mortality in the US: a systematic review and meta-analysis.

Thomas P Lawler, Lauren Giurini, Cibele Barbosa Carroll, Jennifer M Weiss, Noelle K LoConte, Shaneda Warren Andersen

Abstract readSystematic ReviewMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Social science & medicine (1982), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Thomas P LawlerCarbone Cancer Center, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, 53726, USA.
Lauren GiuriniCarbone Cancer Center, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, 53726, USA; Department of Population Health Sciences, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, 53726, USA.
Cibele Barbosa CarrollCarbone Cancer Center, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, 53726, USA.
Jennifer M WeissCarbone Cancer Center, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, 53726, USA; Department of Medicine, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, 53726, USA.
Noelle K LoConteCarbone Cancer Center, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, 53726, USA; Department of Medicine, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, 53726, USA.
Shaneda Warren AndersenCarbone Cancer Center, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, 53726, USA; Department of Population Health Sciences, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, 53726, USA. Electronic address: snandersen@wisc.edu.

Funding

UW COMPREHENSIVE CANCER CENTER SUPPORTP30CA014520 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI Justine Yang Bruce · 1985 to 2026
$142.6M
POPULATION, LIFE COURSE, AND AGINGT32AG000129 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI Michal Engelman · 1986 to 2026
$6.0M
NCI NIH HHS P30 CA014520NIA NIH HHS T32 AG000129
6 · The paper itself

Abstract

backgroundGeographic disparities exist for colorectal cancer (CRC) in the United States (US). Area-level socioeconomic status (SES) may influence CRC outcomes through multiple pathways, including by influencing screening adherence. We completed a systematic review and meta-analysis of area-level SES and CRC incidence, mortality, and screening among US individuals.

methodsOriginal research articles were identified from biomedical databases. Eligible studies reported associations between area-level SES at the census block or tract level with CRC incidence, mortality, or screening in a US-based sample. A fixed-effects meta-analysis was performed to estimate summary hazard ratios (HRs) or odds ratios (ORs) with 95 % confidence intervals (CIs) for the associations between area-level SES and CRC outcomes.

resultsTwenty-six studies were included in the systematic review. Living in an area in the lowest SES quantile was associated with higher CRC risk (HR 1.37 [CI: 1.34-1.41]). Associations were similar in race-stratified analyses for White (HR 1.43 [CI: 1.39-1.47]), Black (HR 1.18 [CI: 0.96-1.44]), and Asian/Pacific Islander racial status (HR 1.18, [CI: 1.08-1.28]). For individuals with CRC, lower area-level SES was associated with risk for overall mortality (HR 1.26 [CI: 1.23-1.29]) and CRC-specific mortality (HR 1.24 [CI: 1.22-1.26]). Lower area-level SES was associated with lower completion of recommended screening for CRC (OR 0.76 [CI: 0.74-0.79]).

conclusionsIndividuals who reside in areas with less socioeconomic resources have elevated risk for CRC incidence and mortality. Healthcare policies and interventions focused on low resource settings may increase uptake of preventative screening leading to a reduction in geographic disparities for CRC.

Indexed as

Colorectal NeoplasmsEarly Detection of CancerSocial ClassHumansIncidenceUnited StatesColorectal cancerDeprivationDisparitiesMortalityScreening

Identifiers

PMID40472644
PMCPMC12255525

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.