Evidence map›Paper›PMID 40472591›Full record

ReviewCurrent opinion in chemical biology2025

Chemical tools to study and modulate glycan-mediated host-bacteria interactions.

Divya Bhargava, Aniqa Chowdhury, Danielle H Dube

Abstract readReview
In one paragraph

Review in Current opinion in chemical biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. AssessingACS infectious diseases · 2026
    Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Divya BhargavaDepartment of Chemistry and Biochemistry, Bowdoin College, 6600 College Station, Brunswick, ME 04011, USA.
Aniqa ChowdhuryDepartment of Chemistry and Biochemistry, Bowdoin College, 6600 College Station, Brunswick, ME 04011, USA.
Danielle H DubeDepartment of Chemistry and Biochemistry, Bowdoin College, 6600 College Station, Brunswick, ME 04011, USA. Electronic address: ddube@bowdoin.edu.

Funding

Deciphering Helicobacter pylori's glycocode: uncovering & harnessing drug targetsR15GM109397 · NIGMS · BOWDOIN COLLEGE · PI DUBE, DANIELLE H. · 2015 to 2021
$1.1M
NIGMS NIH HHS R15 GM109397
6 · The paper itself

Abstract

Glycans cover the surfaces of all cells, where they are poised to mediate a two-way discourse between bacteria and host cells. In some instances, glycan-mediated interactions foster a symbiotic state, and in others, they tip the balance toward disease. Chemical biology approaches have begun to reveal the roles of glycans in host-bacteria interactions and provide novel pathways to modulate these interactions. Here, we highlight recent advances in the development and application of chemical biology tools to delineate the roles of glycans in bacterial adhesion, bacterial evasion of the host immune system, host recognition of bacterial cells, and endogenous mechanisms to maintain symbiosis. Further, we present glycan-based strategies to disrupt host-pathogen interactions and to promote the growth of beneficial bacteria.

Indexed as

BacteriaHost-Pathogen InteractionsPolysaccharidesAnimalsBacterial AdhesionHumansSymbiosisPolysaccharides

Identifiers

PMID40472591
PMCPMC12240235

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.