ArticleInternational journal of surgery case reports2025
Intravesical doxorubicin induced bladder contracture that led to cystectomy: a case series.
Article in International journal of surgery case reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
introduction and importanceDoxorubicin is a popular anthracycline antibiotic that exerts its anticancer effects through various mechanisms. Treatment protocols typically involve an initial induction phase followed by a maintenance phase. CASE SERIES: We present two cases (ages: 66, 75 years) with superficial transitional cell carcinoma of the bladder. They developed severe bladder contracture after transurethral resection of the bladder, followed by intravesical doxorubicin. Then required radical cystectomy and urinary diversion. CLINICAL DISCUSSION: The intravesical instillation comes with the benefit of lower systemic side effects than systemic administration. Bladder contracture following intravesical doxorubicin is very rare.
conclusionSevere bladder contracture is a very rare but serious side effect of intravesical therapy. This incident can affect the patient's quality of life and may even lead to cystectomy. Objective monitoring of bladder capacity is recommended for those patients.
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