Evidence map›Paper›PMID 40472441›Full record

ArticleClinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology2025

Force control deficits in rapid eye movement behavior disorder and Parkinson's disease.

Emily R Tobin, Stefan Delmas, Joongsuk J Kim, Jessica C Hubbard, Basma Yacoubi, XiangYang Lou, Michael F Presti, Allison Kraus, Richard B Berry, Michael S Jaffee and 2 more

Abstract read
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In one paragraph

Article in Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Emily R TobinDepartment of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL 32611, USA. Electronic address: tobine@ufl.edu.
Stefan DelmasDepartment of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL 32611, USA. Electronic address: stefan.demas@colostate.edu.
Joongsuk J KimDepartment of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL 32611, USA. Electronic address: joongsuk.kim@ufl.edu.
Jessica C HubbardDepartment of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL 32611, USA. Electronic address: jessica.hubbard@ufl.edu.
Basma YacoubiDepartment of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL 32611, USA. Electronic address: basma@ufl.edu.
XiangYang LouDepartment of Biostatistics, University of Florida, Gainesville, FL 32610, USA. Electronic address: xlou@ufl.edu.
Michael F PrestiDepartment of Medicine, Division of Pulmonary, Critical Care and Sleep, University of Florida, Gainesville, FL 32610, USA. Electronic address: Michael.Presti@medicine.ufl.edu.
Allison KrausDepartment of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA. Electronic address: alk127@case.edu.
Richard B BerryDepartment of Medicine, Division of Pulmonary, Critical Care and Sleep, University of Florida, Gainesville, FL 32610, USA. Electronic address: richard.berry@medicine.ufl.edu.
Michael S JaffeeDepartment of Neurology, University of Florida, Gainesville, FL 32610, USA. Electronic address: michael.jaffee@neurology.ufl.edu.
Evangelos A ChristouDepartment of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL 32611, USA; Department of Neurology, University of Florida, Gainesville, FL 32610, USA. Electronic address: eachristou@ufl.edu.
David E VaillancourtDepartment of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL 32611, USA; Department of Biomedical Engineering, University of Florida, Gainesville, FL 32610, USA; Department of Neurology, University of Florida, Gainesville, FL 32610, USA. Electronic address: vcourt@ufl.edu.

Funding

Role of the Cortex and Cerebellum in Visually-Guided Motor BehaviorR01NS058487 · NINDS · UNIVERSITY OF ILLINOIS AT CHICAGO · PI JAFFEE, MICHAEL S., VAILLANCOURT, DAVID E · 2008 to 2025
$6.1M
Interdisciplinary Training in Movement Disorders and NeurorestorationT32NS082168 · NINDS · UNIVERSITY OF FLORIDA · PI Melissa Jo Armstrong, David E Vaillancourt · 2015 to 2026
$2.8M
NINDS NIH HHS R01 NS058487NINDS NIH HHS T32 NS082168
6 · The paper itself

Abstract

objectiveThis study aimed to determine if there are deficits in force variability, force increase, force decrease and force errors in rapid eye movement behavior disorder (RBD) using established force control paradigms.

methodsA cohort of 27 controls, 37 RBD and 37 early-stage Parkinson's disease (PD) were investigated. Individuals completed constant force and ballistic force control for the finger and ankle.

resultsThere was greater force variability in RBD compared with controls and PD during the constant force tasks (p < 0.05). Additionally, we split the RBD group into those with mild and moderate motor impairments and found both groups had higher force variability compared with controls (p < 0.05). PD were slower at increasing and decreasing force (p < 0.05) and this was not observed in the RBD group.

conclusionThese findings provide new evidence that force variability may be one of the earliest markers of motor dysfunction in RBD before a subsequent diagnosis of neurological disease. SIGNIFICANCE: These findings provide new and important insights into the motor physiological changes in force control in RBD and PD, which may inform future biomarker studies.

Indexed as

Parkinson DiseasePsychomotor PerformanceREM Sleep Behavior DisorderAgedFemaleHumansMaleMiddle AgedForce controlForce variability, ballistic taskParkinson’s diseaseREM sleep behavior disorder

Identifiers

PMID40472441
PMCPMC12320221

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.