Evidence map›Paper›PMID 40472183›Full record

ArticleUltrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology2025

Interpregnancy interval and risk of recurrence following tubal ectopic pregnancy: retrospective cohort study from UK tertiary center.

W M Dooley, J Farren, L V De Braud, S A Solangon, N Thanatsis, B H Al Wattar, D Jurkovic

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Article in Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

W M DooleyEGA Institute for Women's Health, Faculty of Population Health Sciences, University College London (UCL), London, UK.ORCID 0000-0002-0391-4989
J FarrenEGA Institute for Women's Health, Faculty of Population Health Sciences, University College London (UCL), London, UK.
L V De BraudEGA Institute for Women's Health, Faculty of Population Health Sciences, University College London (UCL), London, UK.
S A SolangonEGA Institute for Women's Health, Faculty of Population Health Sciences, University College London (UCL), London, UK.ORCID 0000-0002-3293-5949
N ThanatsisEGA Institute for Women's Health, Faculty of Population Health Sciences, University College London (UCL), London, UK.
B H Al WattarBeginning Assisted Conception Unit, Epsom and St Helier University Hospitals, London, UK.ORCID 0000-0001-8287-9271
D JurkovicEGA Institute for Women's Health, Faculty of Population Health Sciences, University College London (UCL), London, UK.ORCID 0000-0001-6487-5736

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo assess the effect of interpregnancy interval on the odds of recurrence of tubal ectopic pregnancy (TEP) following expectant or surgical management.

methodsThis was a retrospective cohort study conducted at a tertiary early pregnancy unit (EPU) in London, UK. Patients diagnosed with TEP following spontaneous conception, who had expectant or surgical management and who attended the EPU between December 2008 and January 2021 were included. Univariate and multivariate regression analyses were conducted to explore the association between the odds of recurrence of ectopic pregnancy and various factors, including maternal history, interpregnancy interval and management method of the index TEP, and analyses were adjusted for confounders. The main outcome measure was the odds of recurrence of extrauterine ectopic pregnancy in women presenting with a subsequent pregnancy.

resultsA total of 1386 women with TEP were included, of whom 626 (45.2%) presented with a subsequent pregnancy. Fifty-nine of these women were excluded, as their subsequent pregnancy was conceived via in-vitro fertilization. From the remaining 567 women, 59 (10.4%) were diagnosed with recurrent extrauterine ectopic pregnancy. An interpregnancy interval of 6-18 months was associated with four times the odds of recurrence compared with an interval of ≤ 3 months (odds ratio (OR), 4.05 (95% CI, 1.37-12.03)). Women with two or more previous TEPs had more than three times the odds of recurrence compared to those with one previous TEP (OR, 3.27 (95% CI, 1.13-9.42)). Surgical management of the index TEP was associated with similar odds of recurrence as expectant management (OR, 1.26 (95% CI, 0.72-2.20)).

conclusionsRapid conception after TEP is associated with low odds of recurrence. Therefore, purposeful delay to conception after TEP, including those managed expectantly, should not be recommended. Women with conception delay or a history of more than one ectopic pregnancy are at high risk of recurrent extrauterine ectopic pregnancy. © 2025 The Author(s). Ultrasound in Obstetrics & Gynecology published by John Wiley & Sons Ltd on behalf of International Society of Ultrasound in Obstetrics and Gynecology.

Indexed as

Birth IntervalsPregnancy, TubalAdultFemaleHumansLondonPregnancyRecurrenceRetrospective StudiesRisk FactorsTertiary Care CentersUnited Kingdomectopic pregnancyextrauterine pregnancypregnancy complicationstubal pregnancy

Identifiers

PMID40472183
PMCPMC12209686

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.