Observational studyJournal of cardiovascular medicine (Hagerstown, Md.)2025
Predictive value of age, estimated glomerular filtration rate and ejection fraction (AGEF) score for all-cause 90-day mortality in patients with cardiogenic shock.
Observational study in Journal of cardiovascular medicine (Hagerstown, Md.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Cardiogenic Shock Management in the Modern Era: A Narrative Review of Percutaneous Mechanical Circulatory Support Devices.Journal of cardiovascular development and disease · 2025Review
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5 authors.
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Abstract
aimsAge, estimated glomerular filtration rate and ejection fraction (AGEF) score correlates with mortality in patients with ST-elevation myocardial infarction, yet its relationship with cardiogenic shock mortality remains unknown.
objectivesThis research aims to explore the correlation between AGEF and the probability of all-cause 90-day mortality in patients with cardiogenic shock.
methodsOur study included 168 cardiogenic shock patients from a multicenter, prospective, observational study. The Cox regression model, subgroup analyses, Kaplan-Meier survival curves, and restricted cubic spline analysis were applied to assess the relationship between AGEF and 90-day mortality. Receiver-operating characteristic curve analysis was performed to evaluate the predictive accuracy of AGEF for 90-day mortality.
resultsHigh AGEF scores correlated with significantly higher mortality (56.1 vs. 19.7%, P < 0.05). AGEF was significantly associated with 90-day mortality [hazard ratio: 1.33, per 1-point increase, 95% confidence interval (95% CI) 1.03-1.70, P < 0.001; hazard ratio: 1.65, per 1 standard deviation increase, 95% CI 1.27-2.14, P < 0.001]. The high AGEF group had a two-fold higher risk of 90-day mortality (hazard ratio: 3.08, 95% CI 1.48-6.41, P < 0.001). Kaplan-Meier curve analysis revealed a higher probability of 90-day death in the group with higher AGEF scores. The restricted cubic spline analysis also suggested a linear relationship between AGEF and 90-day mortality. The area under the receiver-operating characteristic curve for the AGEF was 0.71 (95% CI 0.633-0.787), indicating moderate discrimination ability.
conclusionAGEF is significantly associated with all-cause 90-day mortality in patients experiencing cardiogenic shock, indicating its potential as a prognostic indicator in this patient population.
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