ArticleScience (New York, N.Y.)2025
GPR45 modulates Gα
Abstract read
In one paragraph
Article in Science (New York, N.Y.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed.
- Primary cilium as a sensory organelle and metabolic hub in health and diseases.Journal of biomedical science · 2026Review
- Primary cilia: master conductors of cellular communication in development and disease.Nature reviews. Nephrology · 2026Review
- Hyperglycemic stress aggravates diabetic retinopathy and nephropathy by promoting cilium disassembly via a deacetylation- and methylation-mediated regulatory mechanism.PLoS biology · 2026Article
- A Lineup for Next Anti-Obesity Medicines: Beyond Incretin-Based Pharmacotherapy.Pharmaceuticals (Basel, Switzerland) · 2026Review
- Primary cilia dysfunction: A critical driver of metabolic diseases (Review).International journal of molecular medicine · 2026Review
- International Union of Basic and Clinical Pharmacology. CXXII. Applying an objective evaluation to the status of class A orphan G protein-coupled receptors.Pharmacological reviews · 2026Review
- Compartmentalized Nutrient and Hormone Sensing in β-Cells: the Role of Primary Cilia.Physiology (Bethesda, Md.) · 2026Review
- Primary Cilia as Integrative Hubs of Metabolic Signaling in Type 2 Diabetes: Inter-Organ Evidence From Central, Peripheral, and Pancreatic Islet Tissues.Journal of cellular physiology · 2026Review
- Recent developments in GPCR signalling in appetite regulation.Bioscience reports · 2026Review
- From identity to function: unveiling the cellular complexity of hypothalamic feeding circuits.Reviews in endocrine & metabolic disorders · 2026Review
- Smoothened and ciliary GPCRs regulate ciliary protein kinase A activity involved in Hedgehog signal transduction.PLoS biology · 2026Article
- A Novel Cell-Cell Communication Structure: Tanycyte and Cilia Hypothalamic Unifying Glia-cilia Structure (HUGS).microPublication biology · 2026Article
- Lipid ciliology: specialized ciliary membrane lipids in physiology and disease.Frontiers in cell and developmental biology · 2026Review
- Transcriptome analysis reveals reduced lipid accumulation and mitochondrial metabolic remodeling in ADCY3-overexpressing adipocytes.Functional & integrative genomics · 2025Article
- Leptin and G-protein coupled receptor (GPCR) signaling: Therapeutic potential in obesity.The Journal of biological chemistry · 2025Review
- Design principles of ciliary signaling.Journal of cell science · 2025Review
- Review
- The complex role of brain cilia in feeding control.Science (New York, N.Y.) · 2025Article
Corrections and comments
- Commented on by
Authors and funding
10 authors.
Yu Xun *Center for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID 0000-0002-5546-8984
Yiao Jiang *Center for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID 0000-0001-8236-4868
Baijie XuThe Hypothalamic Research Center, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID 0000-0001-7853-1213
Miao TangCenter for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID 0000-0002-8708-3296
Sara LudwigCenter for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Kazuhiro NakamuraDepartment of Integrative Physiology, Nagoya University Graduate School of Medicine, Nagoya, Japan.ORCID 0000-0002-6095-8996
Saikat MukhopadhyayDepartment of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID 0000-0003-4790-3090
Chen LiuThe Hypothalamic Research Center, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID 0000-0002-5922-0951
Bruce BeutlerCenter for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID 0000-0002-3639-246X
Zhao ZhangCenter for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID 0000-0001-9345-3663
Funding
Automated Forward Genetic Analysis of Adaptive ImmunityR01AI125581 · NIAID · UT SOUTHWESTERN MEDICAL CENTER · PI BRUCE A BEUTLER · 2016 to 2026
$19.5MUT Southwestern NORCP30DK127984 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI Jeffrey M Zigman · 2022 to 2026
$7.4MHypothalamic Serotonin Receptors and Olanzapine-induced Metabolic SyndromeR01DK114036 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI Chen Liu · 2017 to 2026
$4.2MTranscriptional Control of Melanocortin 4 Receptors and Obesity RiskR01DK130892 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI Chen Liu · 2022 to 2026
$2.4MSignaling at the primary cilium in development and diseaseR35GM144136 · NIGMS · UT SOUTHWESTERN MEDICAL CENTER · PI Saikat Mukhopadhyay · 2022 to 2026
$1.6MDeconstruct Raphe Serotonin Neurons that Regulate SatietyR01DK136592 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI Chen Liu · 2024 to 2026
$1.5MThe Role of KBTBD2 in Lipodystrophy, Insulin Resistance, and DiabetesR00DK115766 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI ZHANG, ZHAO · 2020 to 2022
$747kNIAID NIH HHS R01 AI125581NIDDK NIH HHS P30 DK127984NIDDK NIH HHS R00 DK115766NIDDK NIH HHS R01 DK114036NIDDK NIH HHS R01 DK130892NIDDK NIH HHS R01 DK136592NIGMS NIH HHS R35 GM144136
Abstract
The melanocortin system centrally regulates energy homeostasis, with key components such as melanocortin-4 receptor (MC4R) and adenylyl cyclase 3 (ADCY3) in neuronal primary cilia. Mutations in
Indexed as
CiliaEatingGTP-Binding Protein alpha Subunits, GsObesityParaventricular Hypothalamic NucleusReceptors, G-Protein-CoupledAdenylyl CyclasesAnimalsCyclic AMPFemaleHyperphagiaMaleMiceMice, Inbred C57BLMice, KnockoutMutation, Missenseadenylate cyclase 3Adenylyl CyclasesCyclic AMPGpr45 protein, mouseGTP-Binding Protein alpha Subunits, GsMC4R protein, mouseReceptor, Melanocortin, Type 4Receptors, G-Protein-Coupled
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.