Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
8 authors.
Cheng-Hai ZhangDepartment of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute at Harvard Medical School, Boston, MA 02115.ORCID 0000-0002-6759-3782
Aref ShahiniDepartment of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute at Harvard Medical School, Boston, MA 02115.ORCID 0000-0002-2744-2875
Laura E CookEnvironmental Genomics and Systems Biology Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720.ORCID 0000-0002-4459-2592
Meeta MistryBioinformatics Core, Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA 02115.ORCID 0000-0002-5830-9479
Jongkil KimDepartment of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute at Harvard Medical School, Boston, MA 02115.ORCID 0000-0001-5441-0484
Heather WickBioinformatics Core, Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA 02115.
Len A PennacchioEnvironmental Genomics and Systems Biology Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720.ORCID 0000-0002-8748-3732
Andrew B LassarDepartment of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute at Harvard Medical School, Boston, MA 02115.ORCID 0000-0002-4573-8645
Funding
Generation of an In Vivo Human Genome Transcriptional Enhancer DatasetR01HG003988 · NHGRI · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI Len Alexander Pennacchio · 2006 to 2026
$24.1M
The Role of Creb5 in Maintaining Synovial Joint HomeostasisR01AR076562 · NIAMS · HARVARD MEDICAL SCHOOL · PI Andrew Bruce Lassar · 2022 to 2026
$3.4M
Elucidation of the Role of Creb5 in Synovial Joint FormationR01AR074385 · NIAMS · HARVARD MEDICAL SCHOOL · PI LASSAR, ANDREW BRUCE · 2019 to 2024
$3.4M
Elucidation of the role of Creb5 in promoting the formation and patterning of the intervertebral discR21AR081990 · NIAMS · HARVARD MEDICAL SCHOOL · PI ZHANG, CHENGHAI · 2023 to 2024
$403k
Arthritis National Research Foundation (ANRF) 707225HHS | NIH | National Human Genome Research Institute (NHGRI) R01HG003988HHS | NIH | National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) R01AR074385HHS | NIH | National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) R01AR076562HHS | NIH | National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) R21AR081990NHGRI NIH HHS R01 HG003988NIAMS NIH HHS R01 AR074385NIAMS NIH HHS R01 AR076562NIAMS NIH HHS R21 AR081990U.S. Department of Energy (DOE) DE-AC02-05CH11231
6 · The paper itself
Abstract
Prior studies have indicated that the transcription factor
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Creb5 controls its own expression and directly induces the joint interzone regulatory program. · full record | OpenQuestion