Evidence map›Paper›PMID 40472030›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

Increased excitatory synapse size in hippocampal place cells compared to silent cells.

Judit Heredi, Gaspar Olah, Mate Sumegi, Istvan Paul Lukacs, Mohammad Aldahabi, Balázs B Újfalussy, Judit K Makara, Zoltan Nusser

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Increased excitatory synapse size in hippocampal place cells compared to silent cells.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Judit Heredi *Laboratory of Cellular Neurophysiology, Hungarian Research Network Institute of Experimental Medicine, Budapest 1083, Hungary.ORCID 0000-0002-8248-3485
Gaspar Olah *Laboratory of Cellular Neurophysiology, Hungarian Research Network Institute of Experimental Medicine, Budapest 1083, Hungary.
Mate SumegiLaboratory of Cellular Neurophysiology, Hungarian Research Network Institute of Experimental Medicine, Budapest 1083, Hungary.
Istvan Paul LukacsLaboratory of Cellular Neurophysiology, Hungarian Research Network Institute of Experimental Medicine, Budapest 1083, Hungary.
Mohammad AldahabiLaboratory of Cellular Neurophysiology, Hungarian Research Network Institute of Experimental Medicine, Budapest 1083, Hungary.ORCID 0000-0001-5397-5416
Balázs B ÚjfalussyLaboratory of Biological Computation, Hungarian Research Network Institute of Experimental Medicine, Budapest 1083, Hungary.ORCID 0000-0002-2295-3828
Judit K MakaraLaboratory of Neuronal Signaling, Hungarian Research Network Institute of Experimental Medicine, Budapest 1083, Hungary.ORCID 0000-0001-8134-6334
Zoltan NusserLaboratory of Cellular Neurophysiology, Hungarian Research Network Institute of Experimental Medicine, Budapest 1083, Hungary.ORCID 0000-0001-7004-4111

Funding

EC | European Research Council (ERC) ERC-AG 787157european reseach council ERC-CoG 771849HHMI (HHMI) 55008740Hungarian Academy of Sciences NAP2022-I-1/2022
6 · The paper itself

Abstract

Neuronal activity in the hippocampus creates a cognitive map of space that is essential for navigation. In any given environment, a fraction of hippocampal pyramidal cells (PCs) is active at specific locations (place cells), others are sparsely active without spatial tuning, and a significant proportion of the PCs is entirely silent. The mechanisms underlying the vastly different activities of PCs in the rodent hippocampal CA1 area are unknown. Here, we measured the in vivo activity of CA1 PCs using two-photon [Ca

Indexed as

CA1 Region, HippocampalHippocampusPlace CellsPyramidal CellsSynapsesAnimalsDendritic SpinesMaleMiceMice, Inbred C57BLNeuronal PlasticityPatch-Clamp Techniqueshippocampusimagingpatch-clampplace cellssynaptic plasticity

Identifiers

PMID40472030
PMCPMC12167973

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.