Article in American journal of physiology. Heart and circulatory physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
6 authors.
Madalena D CostaDivision of Interdisciplinary Medicine and Biotechnology, Department of Medicine, Beth Israel Deaconess Medical Center/Harvard Medical School, Boston, Massachusetts, United States.ORCID 0000-0002-7666-9208
Susan RedlineDivision of Sleep and Circadian Disorders, Department of Medicine, Brigham and Women's Hospital/Harvard Medical School, Boston, Massachusetts, United States.ORCID 0000-0002-6585-1610
Roger B DavisDivision of General Medicine, Department of Medicine, Beth Israel Deaconess Medical Center/Harvard Medical School, Boston, Massachusetts, United States.
Murray MittlemanDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, United States.ORCID 0000-0001-9788-7274
Ary L GoldbergerDivision of Interdisciplinary Medicine and Biotechnology, Department of Medicine, Beth Israel Deaconess Medical Center/Harvard Medical School, Boston, Massachusetts, United States.
Susan R HeckbertDepartment of Epidemiology, Cardiovascular Health Research Unit, University of Washington, Seattle, Washington, United States.
Funding
Institute for Clinical and Translational ResearchUL1TR001079 · NCATS · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2013 to 2017
$60.1M
Wake Forest Clinical and Translational Science AwardUL1TR001420 · NCATS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI ARD, JAMY D, FOLEY, KRISTIE L · 2015 to 2023
$32.3M
Task Area A Core Study Operations.Task Area A shall encompass annual follow-up of cohort members, clinical endpoints ascertainment, study coordination activities, maintenance of the database and biosp75N92020D00001 · NHLBI · UNIVERSITY OF WASHINGTON · PI MCCLELLAND, ROBYN LEAGH · 2020 to 2025
$17.2M
Longitudinal Relationships Among Sleep, Cognition and Alzheimer's Disease Biomarkers: Discerning Causal Associations, Mediators and SusceptibilityR01AG070867 · NIA · BRIGHAM AND WOMEN'S HOSPITAL · PI PURCELL, SHAUN M, REDLINE, SUSAN S. · 2021 to 2024
$9.9M
ASSOCIATION OF SLEEP DISORDERS WITH CARDIOVASCULAR HEALTH ACROSS ETHNIC GROUPSR01HL098433 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI REDLINE, SUSAN S. · 2010 to 2015
$8.2M
Research Resource for Complex Physiologic SignalsR01EB030362 · NIBIB · BETH ISRAEL DEACONESS MEDICAL CENTER · PI GOLDBERGER, ARY LOUIS · 2020 to 2025
$5.8M
Task Area A shall encompass annual follow-up of cohort members, clinical events investigations, study operations, and data analysis and manuscript writing. If implemented, Task A.1 will provide fundin75N92020D00005 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI WATSON, KAROL E · 2020 to 2025
$5.1M
TO EXERCISE OPTION PERIOD ONE (1) FOR TASK AREA A - MESA CORE OPERATIONS, FIELD CENTER.75N92020D00004 · NHLBI · NORTHWESTERN UNIVERSITY · PI SIEGEL, JONATHAN H · 2020 to 2025
$4.5M
Task Area A shall encompass annual follow-up of cohort members, clinical events investigations, study operations, and data analysis and manuscript writing. If implemented, Task A.1 will provide fundin75N92020D00006 · NHLBI · UNIVERSITY OF MINNESOTA · PI PANKOW, JAMES S · 2020 to 2025
$4.4M
Task Area A shall encompass annual follow-up of cohort members, clinical events investigations, study operations, and data analysis and manuscript writing. If implemented, Task A.1 will provide fundin75N92020D00003 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI POST, WENDY S · 2020 to 2025
$3.8M
Task Area A shall encompass annual follow-up of cohort members, clinical events investigations, study operations, and data analysis and manuscript writing. If implemented, Task A.1 will provide fundin75N92020D00007 · NHLBI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI BERTONI, ALAIN GERALD · 2020 to 2025
$3.5M
Task Area A shall encompass annual follow-up of cohort members, clinical events investigations, study operations, and data analysis and manuscript writing. If implemented, Task A.1 will provide fundin75N92020D00002 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI SHEA, STEVEN J · 2020 to 2025
$3.4M
HHS | NIH | National Center for Advancing Translational Sciences (NCATS) UL1-TR-000040HHS | NIH | National Center for Advancing Translational Sciences (NCATS) UL1-TR-001079HHS | NIH | National Center for Advancing Translational Sciences (NCATS) UL1-TR-001420HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) N01-HC-95159HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) N01-HC-95160HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) N01-HC-95161HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) N01-HC-95162HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) N01-HC-95163HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) N01-HC-95164HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) N01-HC-95165HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) N01-HC-95166HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) N01-HC-95167HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) N01-HC-95168HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) N01-HC-95169HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) R01HL144510HHS | NIH | National Institute of Biomedical Imaging and Bioengineering (NIBIB) R01EB030362ICL | National Heart and Lung Institute (NHLI) R01HL098433NCATS NIH HHS UL1 TR001079NCATS NIH HHS UL1 TR001420NHLBI NIH HHS 75N92020D00001NHLBI NIH HHS 75N92020D00002NHLBI NIH HHS 75N92020D00003NHLBI NIH HHS 75N92020D00004NHLBI NIH HHS 75N92020D00005NHLBI NIH HHS 75N92020D00006NHLBI NIH HHS 75N92020D00007NHLBI NIH HHS HHSN268201500003INHLBI NIH HHS N01 HC095159NHLBI NIH HHS N01 HC095160NHLBI NIH HHS N01 HC095161NHLBI NIH HHS N01 HC095162NHLBI NIH HHS N01 HC095163NHLBI NIH HHS N01 HC095164NHLBI NIH HHS N01 HC095165NHLBI NIH HHS N01 HC095166NHLBI NIH HHS N01 HC095167NHLBI NIH HHS N01 HC095168NHLBI NIH HHS N01 HC095169NHLBI NIH HHS R01 HL098433NHLBI NIH HHS R01 HL144510NIA NIH HHS R01 AG070867NIBIB NIH HHS R01 EB030362U.S. Environmental Protection Agency (EPA) RD831697U.S. Environmental Protection Agency (EPA) RD-83830001
6 · The paper itself
Abstract
Coronary artery calcification (CAC) is the most reliable noninvasive predictor of major adverse cardiovascular events (MACEs). Individuals with no detectable or minimal CAC (Agatston score 1-100) are considered at the lowest risk. However, MACE does occur in these groups. This study evaluated whether quantification of cardiac vagal activity by heart rate fragmentation (HRF) improved MACE risk prediction beyond CAC imaging. Our study population is a cohort of the Multi-Ethnic Study of Atherosclerosis (MESA). Cox regression models were used to assess the association between HRF, derived from polysomnographic ECGs, and incident MACE in the overall cohort with concurrent polysomnographic ECG and CAC data, and three nonoverlapping subgroups: "very-low-risk" (CAC = 0), "low-risk" (0 < CAC < 100), and "elevated-risk" (CAC ≥ 100). Over a median (1st; 3rd quartiles) follow-up period of 8.9 (8.4; 9.4) yr, there were 164, 29, 47, and 88 incident MACEs in the overall cohort (
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Vagal impairment and cardiovascular risk in those with zero to low coronary artery calcification scores: the Multi-Ethnic Study of Atherosclerosis. · full record | OpenQuestion