Evidence map›Paper›PMID 40471684›Full record

ReviewCurrent opinion in neurology2025

Neuroglia's signaling: orchestrating neuronal gamma synchrony?

Mie Andersen, Hajime Hirase, Celia Kjaerby, Maiken Nedergaard

Abstract readReview
In one paragraph

Review in Current opinion in neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Mie AndersenCenter for Translational Neuromedicine, University of Copenhagen, Copenhagen, Denmark.
Hajime HiraseCenter for Translational Neuromedicine, University of Copenhagen, Copenhagen, Denmark.
Celia KjaerbyCenter for Translational Neuromedicine, University of Copenhagen, Copenhagen, Denmark.
Maiken NedergaardCenter for Translational Neuromedicine, University of Copenhagen, Copenhagen, Denmark.

Funding

Viral Tool Development Core: Visualization and manipulation of brain fluid dynamics by recombinant viral vectorsU19NS128613 · NINDS · UNIVERSITY OF ROCHESTER · PI Laura Diane Lewis · 2022 to 2026
$13.6M
The glymphatic system at the crossroad of integrative health approaches inchronic painR01AT011439 · NCCIH · UNIVERSITY OF ROCHESTER · PI NEDERGAARD, MAIKEN · 2021 to 2025
$3.1M
CRCNS: Waste-clearance flows in the brain measured using physics-informed neural networkR01AT012312 · NCCIH · UNIVERSITY OF ROCHESTER · PI Douglas H Kelley · 2022 to 2026
$1.6M
NCCIH NIH HHS R01 AT011439NCCIH NIH HHS R01 AT012312NINDS NIH HHS U19 NS128613
6 · The paper itself

Abstract

purpose of reviewGamma oscillations (30-80 Hz) play a crucial role in sensory processing and cognitive functions, with disruptions in these rhythms linked to neurological disorders such as schizophrenia and Alzheimer's disease. This review highlights the emerging role of astrocytes in regulating gamma oscillations, emphasizing their contribution to the inhibitory tone and extracellular ion homeostasis. RECENT

findingsRecent studies suggest that astrocytes facilitate gamma synchrony, while dysfunction in astrocytic activity - such as impaired Ca 2+ signaling - is associated with deficits in gamma oscillations and increased network hyperexcitability. Thus, astrocytic dysfunction may contribute to the pathophysiology of gamma-related disorders. SUMMARY: By examining the role of astrocytes in maintaining neuronal network stability, this review highlights new aspects of neuroglia signaling.

Indexed as

AstrocytesGamma RhythmNeurogliaNeuronsSignal TransductionAnimalsHumansAlzheimer's diseaseastrocytesgamma oscillationsneuromodulationschizophrenia

Identifiers

PMID40471684
PMCPMC12226229

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.