Evidence map›Paper›PMID 40471648›Full record

ArticlePaediatric and perinatal epidemiology2025

Hypertensive Disorders of Pregnancy, Preterm Delivery, and Infant Size: Which Mothers Have Highest Cardiovascular Disease Mortality?

Sage Wyatt, Rolv Skjærven, Lars Vatten, Allen J Wilcox, Aditi Singh, Kari Klungsøyr, Suzan L Carmichael, Nils-Halvdan Morken, Rolv Terje Lie, Liv Grimstvedt Kvalvik

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In one paragraph

Article in Paediatric and perinatal epidemiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Sage WyattDepartment of Global Health and Primary Care, University of Bergen, Bergen, Norway.
Rolv SkjærvenDepartment of Global Health and Primary Care, University of Bergen, Bergen, Norway.
Lars VattenDepartment of Public Health, Norwegian University of Science and Technology, Trondheim, Norway.
Allen J WilcoxEpidemiology Branch, National Institute of Environmental Health Sciences, Durham, North Carolina, USA.ORCID https://orcid.org/0000-0002-3376-1311
Aditi SinghDepartment of Global Health and Primary Care, University of Bergen, Bergen, Norway.ORCID https://orcid.org/0000-0002-2302-1723
Kari KlungsøyrDepartment of Global Health and Primary Care, University of Bergen, Bergen, Norway.
Suzan L CarmichaelDepartment of Pediatrics, Stanford University School of Medicine, Stanford, California, USA.
Nils-Halvdan MorkenDepartment of Global Health and Primary Care, University of Bergen, Bergen, Norway.
Rolv Terje LieDepartment of Global Health and Primary Care, University of Bergen, Bergen, Norway.
Liv Grimstvedt KvalvikDepartment of Global Health and Primary Care, University of Bergen, Bergen, Norway.ORCID https://orcid.org/0000-0001-6520-9057

Funding

European Research Council
6 · The paper itself

Abstract

backgroundResearch on new-onset hypertensive disorders of pregnancy (HDP) and long-term maternal cardiovascular disease (CVD) death has focused on mothers of small-for-gestational-age infants rather than large-for-gestational-age infants.

objectivesWe further explored this focus by investigating CVD death in mothers with HDP by gestational age at delivery across the full spectrum of infant birth size.

methodsWe used data from the Medical Birth Registry of Norway, the Norwegian National Population Register, and the Norwegian Cause of Death Registry, with information on mothers giving birth 1967-2020. This data was used to predict CVD death in the decades following pregnancy.

resultsWe found the lowest CVD mortality among mothers with no HDP, term delivery, and a first infant with birthweight above average. These women constituted our reference group in the analyses. We found the highest risk of CVD death among mothers with preterm HDP and infants with above average birthweight for gestational age (HR 6.87, 95% CI 4.98, 9.48), not with infants below average birthweight for gestational age (HR 3.06, 95% CI 2.37, 3.93).

conclusionsThere is an interactive association between HDP and large infant birthweight in preterm first births. The high risk associated with the particular combination of HDP, preterm birth, and high infant birthweight for gestational age warrants further research to understand its causal underpinnings.

Indexed as

Birth WeightCardiovascular DiseasesHypertension, Pregnancy-InducedPremature BirthAdultFemaleGestational AgeHumansInfant, NewbornNorwayPregnancyRegistriesRisk FactorsCVDHDPmaternal healthpreeclampsiapregnancy complications

Identifiers

PMID40471648
PMCPMC12391857

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