Evidence map›Paper›PMID 40471549›Full record

ReviewAnnals of the New York Academy of Sciences2025

The rebirth of repressive chromatin during early vertebrate development.

Dilani Rajapakse-Yongue, Mary Goll

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Annals of the New York Academy of Sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Dilani Rajapakse-YongueDepartment of Genetics, University of Georgia, Athens, Georgia, USA.ORCID 0009-0000-6385-612X
Mary GollDepartment of Genetics, University of Georgia, Athens, Georgia, USA.ORCID 0000-0001-5003-6958

Funding

T32 Predoctoral Training Grant in GeneticsT32GM142623 · NIGMS · UNIVERSITY OF GEORGIA · PI Kelly A Dyer, Mary Grace Goll · 2022 to 2026
$2.1M
Heterochromatin in the developing vertebrate embryoR35GM139556 · NIGMS · UNIVERSITY OF GEORGIA · PI GOLL, MARY GRACE · 2021 to 2025
$1.9M
NIGMS NIH HHS R35 GM139556NIGMS NIH HHS T32 GM142623NIH HHS R35GM139556NIH HHS T32GM142623
6 · The paper itself

Abstract

Following fertilization, gamete-specific chromatin configurations must be reset to allow for the rebirth of an embryo-specific chromatin landscape capable of driving organismal development. During early cell divisions, the rebuilding of embryonic chromatin requires the renewed delineation of transcriptionally permissive and repressive chromatin states across the genome. This review summarizes our current understanding of how repressive chromatin states are reborn during vertebrate embryogenesis. We highlight both shared and divergent features across species, emphasizing well-characterized mouse and zebrafish models.

Indexed as

ChromatinChromatin Assembly and DisassemblyEmbryonic DevelopmentVertebratesAnimalsGene Expression Regulation, DevelopmentalHumansMiceZebrafishChromatin5‐methylcytosinechromatindevelopmenthistonematernal‐to‐zygotic transitionmousezebrafish

Identifiers

PMID40471549
PMCPMC12310378

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.