ReviewAnnals of the New York Academy of Sciences2025
Oxytocin and opioid antagonists: A dual approach to improving social behavior.
Review in Annals of the New York Academy of Sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Oxytocin receptor gene expression in the basal forebrain in autism: association with receptor binding levels and single nucleotide polymorphisms.Journal of neurodevelopmental disorders · 2026Article
- Oxytocin receptor gene expression in the basal forebrain in autism: association with receptor binding levels and single nucleotide polymorphisms.Research square · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Social behavior is a cornerstone of mental health and well-being, shaped by complex neuromodulatory processes. Pharmacological interventions targeting social deficits have largely centered around oxytocin (OT). While some clinical trials have shown promising results for OT in addressing social impairments, others have reported inconsistent outcomes, with concerns about its weak and variable effects. The central OT system is exceptionally complex, given its interactions with several neuromodulatory systems. This review explores the dynamic relationship between the OT and opioid systems in regulating social behavior and their potential therapeutic applications. Despite the known physiological relationship between the opioid and OT systems, many questions about the effects of their interaction on social behavior remain unanswered. Recent research investigating the combined effects of OT and opioid antagonists has reported promising results in improving social functioning. Here, we highlight key challenges in this area, including how to manipulate the OT and opioid systems without disrupting their natural balance, understanding their role in real-world social contexts, and achieving precise modulation of their effects. Evaluating these points will require cutting-edge neuroscience techniques, such as optogenetics, CRISPR, and designer ligands, to refine our understanding and pave the way for novel therapeutic strategies to improve social functioning.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.