ArticleProbiotics and antimicrobial proteins2026
Unraveling the Obesity-Combating Potential of Parabacteroides goldsteinii and Bacteroides sartorii: A Dual-Probiotic Approach.
Article in Probiotics and antimicrobial proteins, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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4 citing papers in PubMed.
- Effects of Dietary Supplementation withBiology · 2026Article
- Microalgal Unsaponifiable Matter Ameliorates Estrogen Deficiency-Induced Metabolic Dysfunction Through Intestinal Barrier Restoration and Gut Microbiota Modulation.Molecular nutrition & food research · 2026Article
- Nervonic Acid Prevents HFD-Induced Metabolic Dysfunction and Is Associated with Gut Microbiota Remodeling.Metabolites · 2026Article
- Innovative research of xian-Ling-Gu-bao herbal residue in regulating soluble carbon-to-nitrogen ratio to promote the growth and nutritional quality ofFood chemistry: X · 2026Article
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Authors and funding
10 authors.
Funding
Abstract
Obesity is a common health problem marked by the accumulation of excess body fat beyond the range characteristics of a healthy weight, affecting millions worldwide. Although advancements have been made in the realm of probiotic therapy for obesity, studies on the combined use of probiotics for the treatment of obesity have yet to be well explored. In this study, we investigated the potential of Parabacteroides goldsteinii (P. goldsteinii) and Bacteroides sartorii (B. sartorii) combinations and their microencapsulated forms for treating obesity. We identified different probiotic strains by 16S rRNA analysis in obese and healthy mice. The activity of these probiotics was evaluated in vitro under simulated gastrointestinal conditions. In vivo, the effects of probiotics on obese mice were assessed by monitoring body weight, glucose tolerance, colon integrity, and various molecular markers. Our results suggested that P. goldsteinii and B. sartorii were shown to be less abundant in obese mice (P < 0.05). Compared with the control group mice, the obese phenotypes of the probiotics intervention group mice were significantly improved (P < 0.05). Further results showed that compared with the control group mice, the expression of the FTO in the liver tissue of the probiotics intervention group mice was downregulated (P < 0.05), while the expression of the Ampk gene was upregulated (P < 0.05), indicating that probiotic intervention had reduced the expression of obesity-related genes in mice and had alleviated their obese condition. Furthermore, Microcapsule was remarkably effective in maintaining the viability of probiotics and facilitating their persistence, leading to a significant reduction in weight gain in mice compared with controls within just one week (P < 0.05). Taken together, our study demonstrates that the intervention using the combination of P. goldsteinii and B. sartorii is more effective in treating obesity than using either probiotic alone. The encapsulation approach further enhances the anti-obesity efficacy of the combined probiotic mixture.
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