Evidence map›Paper›PMID 40471516›Full record

ArticleInternational journal of hematology2025

Transient lupus anticoagulant induced by adenovirus cystitis in a bone marrow transplant recipient.

Tatsuya Imi, Hidesaku Asakura, Keijiro Sato, Shinya Yamada, Takeshi Yoroidaka, Yoshitaka Zaimoku, Hiroyuki Maruyama, Kohei Hosokawa, Akiyo Yoshida, Hiroyuki Takamatsu and 5 more

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of hematology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Tatsuya ImiDepartment of Hematology, Faculty of Medicine, Institute of Medical, Pharmaceutical, and Health Sciences, Kanazawa University, 13-1 Takaramachi, Kanazawa, Ishikawa, 920-8640, Japan. t.imi@staff.kanazawa-u.ac.jp.ORCID http://orcid.org/0000-0002-7674-7368
Hidesaku AsakuraDepartment of Hematology, Faculty of Medicine, Institute of Medical, Pharmaceutical, and Health Sciences, Kanazawa University, 13-1 Takaramachi, Kanazawa, Ishikawa, 920-8640, Japan.
Keijiro SatoDepartment of Hematology, Faculty of Medicine, Institute of Medical, Pharmaceutical, and Health Sciences, Kanazawa University, 13-1 Takaramachi, Kanazawa, Ishikawa, 920-8640, Japan.
Shinya YamadaDepartment of Hematology, Faculty of Medicine, Institute of Medical, Pharmaceutical, and Health Sciences, Kanazawa University, 13-1 Takaramachi, Kanazawa, Ishikawa, 920-8640, Japan.
Takeshi YoroidakaDepartment of Hematology, Faculty of Medicine, Institute of Medical, Pharmaceutical, and Health Sciences, Kanazawa University, 13-1 Takaramachi, Kanazawa, Ishikawa, 920-8640, Japan.
Yoshitaka ZaimokuDepartment of Hematology, Faculty of Medicine, Institute of Medical, Pharmaceutical, and Health Sciences, Kanazawa University, 13-1 Takaramachi, Kanazawa, Ishikawa, 920-8640, Japan.
Hiroyuki MaruyamaDepartment of Hematology, Faculty of Medicine, Institute of Medical, Pharmaceutical, and Health Sciences, Kanazawa University, 13-1 Takaramachi, Kanazawa, Ishikawa, 920-8640, Japan.
Kohei HosokawaDepartment of Hematology, Faculty of Medicine, Institute of Medical, Pharmaceutical, and Health Sciences, Kanazawa University, 13-1 Takaramachi, Kanazawa, Ishikawa, 920-8640, Japan.
Akiyo YoshidaDepartment of Hematology, Faculty of Medicine, Institute of Medical, Pharmaceutical, and Health Sciences, Kanazawa University, 13-1 Takaramachi, Kanazawa, Ishikawa, 920-8640, Japan.
Hiroyuki TakamatsuDepartment of Hematology, Faculty of Medicine, Institute of Medical, Pharmaceutical, and Health Sciences, Kanazawa University, 13-1 Takaramachi, Kanazawa, Ishikawa, 920-8640, Japan.
Ken IshiyamaDepartment of Hematology, Faculty of Medicine, Institute of Medical, Pharmaceutical, and Health Sciences, Kanazawa University, 13-1 Takaramachi, Kanazawa, Ishikawa, 920-8640, Japan.
Hirohito YamazakiDepartment of Hematology, Faculty of Medicine, Institute of Medical, Pharmaceutical, and Health Sciences, Kanazawa University, 13-1 Takaramachi, Kanazawa, Ishikawa, 920-8640, Japan.
Hikaru KobayashiDepartment of Hematology, Nagano Red Cross Hospital, 5-22-1, Wakasato, Nagano, Nagano, 380-8582, Japan.
Shinji NakaoDepartment of Hematology, Faculty of Medicine, Institute of Medical, Pharmaceutical, and Health Sciences, Kanazawa University, 13-1 Takaramachi, Kanazawa, Ishikawa, 920-8640, Japan.
Toshihiro MiyamotoDepartment of Hematology, Faculty of Medicine, Institute of Medical, Pharmaceutical, and Health Sciences, Kanazawa University, 13-1 Takaramachi, Kanazawa, Ishikawa, 920-8640, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Adenovirus-associated hemorrhagic cystitis (AdV-HC) is a serious complication of hematopoietic stem cell transplantation (HSCT) that requires hemostatic therapies to control severe hematuria. Here we present the case of a 65-year-old woman with acute myeloid leukemia who successfully underwent HSCT, but developed AdV-HC followed by adenovirus viremia. Marked prolongation of activated partial thromboplastin time (APTT) was observed, along with a decrease in all coagulation factors except prothrombin, raising suspicion of a coagulation factor deficiency. A workup including the APTT cross-mixing test, diluted Russell's viper venom time, and phospholipid neutralization assays revealed the presence of lupus anticoagulant (LA), indicating a thrombotic tendency due to LA associated with artifactual lowering of coagulation factors. Based on these findings, no hemostatic agents were used to manage macroscopic hematuria, and all coagulation test results spontaneously normalized with the resolution of adenovirus viremia, without any thrombus formation. Patients with AdV-HC and prolonged APTT should be screened for LA to avoid inappropriate use of hemostatic agents.

Indexed as

Adenoviridae InfectionsBone Marrow TransplantationCystitisHematopoietic Stem Cell TransplantationLupus Coagulation InhibitorAdenoviridaeAgedFemaleHematuriaHumansLeukemia, Myeloid, AcuteViremiaLupus Coagulation InhibitorAdenovirusHemorrhagic cystitisLupus anticoagulantTransplantation

Identifiers

PMID40471516
PMCPMC12476403

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.