ArticleNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2025
Impaired glymphatic function assessed by DTI-ALPS in drug-naïve Parkinson's disease and its association with motor and non-motor symptoms.
Article in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- The glymphatic system and Parkinson's disease: a narrative review.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026Review
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8 authors.
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Abstract
background and purposeGlymphatic dysfunction is implicated in Parkinson's disease (PD), contributing to α-synuclein accumulation. This study investigates glymphatic activity in drug-naïve PD patients using the diffusion tensor imaging-analysis along the perivascular space (DTI-ALPS) and explores its correlation with clinical symptoms.
methodsWe included 23 drug-naïve PD patients and 23 age-matched healthy controls (HCs) from Chengdu Second People's hospital between November 2022 to October 2023. The DTI-ALPS index was calculated for both hemispheres to assess glymphatic function. Clinical data, including Hoehn and Yahr (H&Y) stage, new Freezing of Gait Questionnaire (n-FOGQ), International Restless Legs Syndrome (IRLS) scores, and the Mini-Mental State Examination (MMSE) scores, were collected. Correlations between the DTI-ALPS index and clinical measures were analyzed. Receiver operating characteristic was performed to test the predictive value of DTI-ALPS index.
resultsPD patients showed significantly reduced both in the left and right hemispheric DTI-ALPS index compared to HCs (P < 0.001). The right hemisphere DTI-ALPS index positively correlated with MMSE scores but negatively correlated with the H&Y stage. The left hemisphere DTI-ALPS index positively correlated with n-FOGQ and IRLS scores. ROC analysis showed an area under the curve of 0.936 for left-hemispheric DTI-ALPS in distinguishing PD from HCs.
conclusionReduced glymphatic dysfunction, assessed by the DTI-ALPS index, was associated with both motor and non-motor symptoms in drug-naïve PD, suggesting its potential as a non-invasive biomarker for PD, offering new directions for targeted therapeutic interventions.
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