ArticleDiscover oncology2025
Multi-omics exploration of CAV1
Article in Discover oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
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Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
backgroundOral squamous cell carcinoma originating from the gingiva and buccal mucosa (OSCC-GB) is closely associated with complex molecular mechanisms and immune evasion phenomena within the tumor microenvironment. This study aims to reveal the characteristics of tumor epithelial cell subcelltypes and their roles in tumor progression.
methodsWe organized and analyzed single-cell RNA sequencing (scRNA-seq) data from Oral squamous cell carcinoma (OSCC), categorizing tumor epithelial cells into six subcelltypes. Utilizing spatial transcriptomics, we investigated the spatial distribution of these subcelltypes. The focus was on the high malignancy tumor epithelial subcelltype, aiming to identify specific transcription factors and analyze their effects on cell status and function. Furthermore, we examined the interactions between the high malignancy tumor epithelial subcelltype and immune cells within the tumor immune microenvironment, along with the underlying mechanisms.
resultsOur findings indicate that the CAV1
conclusionThis study elucidates the critical role of the CAV1
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