ArticleCellular and molecular life sciences : CMLS2025
SNORD88B promotes proliferation and invasion of trophoblast by regulating G3BP1 m6 A modification and alternative splicing.
Article in Cellular and molecular life sciences : CMLS, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Crosstalk between alternative splicing and non-coding RNAs in hepatocellular carcinoma: from regulatory mechanism to therapeutic implications.Non-coding RNA research · 2026Review
- Dysregulation of SCARB1 Alternative Splicing Disturbs Amino Acid Metabolism in Anembryonic Pregnancy.Reproductive sciences (Thousand Oaks, Calif.) · 2026Article
- Small Nucleolar RNAs (snoRNAs) in Cancer: From Biogenesis to Clinical Potential.OncoTargets and therapy · 2026Review
- Integrative analysis of a novel snoRNA-based prognostic signature in patients with breast cancer.Frontiers in oncology · 2026Article
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8 authors.
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Abstract
backgroundSmall nucleolar RNA (snoRNA) has recently been shown to play a key role in different diseases, but how snoRNA works to promote the biological behavior of trophoblast remains unclear.
methodsThe expression of snoRNA in the placental villi of females were detected by RNA-seq and qPCR. RNA immunoprecipitation (RIP), RNA methylation co-immunoprecipitation (Me-RIP), and cell experiments were used to explore the molecular mechanism of SNORD88B in regulating the function of villous trophoblasts.
resultsSNORD88B was down-regulated in the placental villi of patients with spontaneous abortion, while the overexpression of SNORD88B could promote the proliferation, invasion, and migration of villous trophoblast cells. Mechanistically, SNORD88B directly binds to m6A methyltransferase METTL14 to regulate the m6A modification of G3BP1 mRNA and enhances its mRNA stability by recruiting the reader IGF2BP2. Besides, SNORD88B also regulates the alternative splicing of pre-G3BP1 by recruiting splicing factors SRSF1 and U2AF1, which ameliorates the expression of its effective transcripts to further promote the expression of G3BP1 protein.
conclusionsWe investigated the functional roles and the underlying regulatory mechanisms of SNORD88B in the enhancement of villous trophoblasts' development and that under-expressed SNORD88B could contribute to the maldevelopment of placental villi, which may be related to spontaneous abortion.
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