ArticleJournal of molecular histology2025
Quercetin mitigates sepsis-induced renal injury via inhibiting inflammatory and oxidative pathways in mice.
Article in Journal of molecular histology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Topical ronomilast alone or combined with clobetasol ameliorates imiquimod-induced psoriasis in mice.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Paeoniflorin Ameliorates Cecal Ligation and Puncture-Induced Acute Lung Injury in Mice by Modulating Oxidative Stress, Apoptosis, and Inflammation: Shedding Light on the Role of the JAK2/STAT3 Pathway.Pharmaceuticals (Basel, Switzerland) · 2026Article
- Nephroprotective Effect of L-Carvone on a Mouse Model of LPS-Induced Sepsis-Associated Renal Injury via Regulation of TLR4/NF-κB/AP-1/IRF-3 and Nrf2/iNOS Molecular Signaling Cascades.Journal of Taibah University Medical Sciences · 2026Article
- Quercetin in skin burn healing: mechanisms, advanced delivery systems, and translational perspectives.Frontiers in bioengineering and biotechnology · 2026Review
- Brain-Region-Mediated Neuroimmune Modulation in Sepsis: Research Advances and Therapeutic Prospects.Journal of inflammation research · 2026Review
- L-carvone alleviates lipopolysaccharide-Induced acute kidney injury via modulating MyD88-dependent and independent signaling pathways in Mice.Molecular biology reports · 2025Article
- Gemifloxacin ameliorates acetic acid-induced ulcerative colitis via modulation of inflammatory, oxidative, and adhesive biomarkers and histopathological changes in rats.Journal of molecular histology · 2025Article
- Enhancing the Antidepressant Efficacy of Quercetin via Brain-Targeted Lipid Nanocarriers: Fabrication, Characterization, and Evaluation.International journal of nanomedicine · 2025Article
- The Effect of Ozone on Kidney and Liver Tissues in the Treatment of Sepsis Caused by Cecal Perforation in Diabetic Mice.Drug design, development and therapy · 2025Article
- Evaluation ofTranslational animal science · 2025Article
- The Role of Mitochondrial Dysfunction in Sepsis-Associated Acute Kidney Injury: A Narrative Review.Drug design, development and therapy · 2025Review
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sepsis is the primary cause of mortality after infection and is considered a global health issue. This study aimed to investigate whether quercetin may have any potential nephroprotective effects during renal injury induced by sepsis. 40 male albino Swiss mice were divided into 4 groups of 10 mice each. Normal control groups include mice that clearly exhibit good health. The CLP group included mice that underwent cecal ligation and puncture (CLP) surgery but received no treatment. Dimethyl sulfoxide (DMSO) group administered DMSO as a vehicle. The quercetin group was administered quercetin 10 mg/kg/day intraperitoneally for 5 consecutive days. A significant (p < 0.05) reduction in the renal levels of Neutrophil gelatinase-associated lipocalin (NGAL) was observed in the quercetin group compared to the CLP group. A significant (p < 0.05) reduction in the serum levels of inflammatory cytokines (TNF-α, IL-6, and IL-1β) was observed in the quercetin group compared to the CLP group. Additionally, the quercetin group exhibited a significant (p < 0.05) increase in renal SOD activity and a reduction in MDA levels in comparison to the CLP group. Histologically, all mice in the CLP group exhibited a significant (p < 0.05) renal tissue injury, whereas the quercetin group exhibited a significant (p < 0.05) reduction in renal tissue injury. The quercetin exhibited an anti-inflammatory effect by reducing serum levels of inflammatory cytokines (TNF-α, IL-1β, and IL-6), as well as an antioxidant effect by decreasing renal levels of MDA and increasing the renal activity of SOD.
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Registered trials
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