ArticleMolecular biology reports2025
Neurotensin modulates the female reproductive system via extracellular signal-regulated kinase 1/2 signaling pathway: an in vivo and in silico study in mice.
Article in Molecular biology reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- NGF administration is associated with increased GnRH immunoreactivity and a GnRH-associated phenotype in hypothalamic NSCs of aging mice.Frontiers in endocrinology · 2026Article
- Probiotics as an Adjunct Ameliorates Ovarian Toxicity in Endotoxemic Mice via Modulating TLR 4/MyD88/NF-κB Signalling Pathway: Insights from In Vivo and In Silico Study.Reproductive sciences (Thousand Oaks, Calif.) · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe present study elucidated the modulation of the female reproductive system by neurotensin (NTS) receptor 1 (NTSR
methodFemale mice were maintained in three groups (12/group): Group I-control, Group II and Group III were intraperitoneally exposed with NTSR
resultsTreatment with PD149163 facilitated the ovarian follicular growth, as revealed from the histology; follicular size, granulosa and theca cell layers increased compared to controls. The uterine horn also showed improved endometrium with well-developed endometrial glands. The plasma levels of NTS and LH were significantly increased, while FSH and estradiol showed a non-significant increasing trend. On the contrary, SR48692-treated mice showed a lower level of NTS and all reproductive hormones, but an elevation in the histopathological scores in both the ovary and uterine horn. While there was no alteration in oxidative stress biomarkers in the PD149163-treated mice, the pro-oxidant levels were significantly increased, and the anti-oxidant enzyme activities were reduced on antagonist treatment. Thus, NTS might facilitate ovulation and maintain uterus acting through NTSR
conclusionIn conclusion, NTS receptor analogs may provide a better understanding of the mechanisms by which neurotensin modulates reproduction and could be further exploited for managing various reproductive disorders.
Indexed as
Identifiers
40471330What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.