Evidence map›Paper›PMID 40471309›Full record

ArticleInternational journal of colorectal disease2025

Preoperative immunosuppressive therapy might not affect the length of resected bowel in patients receiving ileocolic resection for Crohn's disease.

Matthias Kelm, Michaela Bredl, Anna Widder, Katrin Schoettker, Markus Brand, Alexander Meining, Regina Pistorius, Joachim Reibetanz, Nicolas Schlegel, Christoph-Thomas Germer and 1 more

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Article in International journal of colorectal disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

11 authors.

Matthias Kelm *Department for General, Transplant, Vascular and Pediatric Surgery, University Hospital of Wuerzburg, Oberduerrbacher Str. 6, 97080, Würzburg, Germany.
Michaela Bredl *Department for General, Transplant, Vascular and Pediatric Surgery, University Hospital of Wuerzburg, Oberduerrbacher Str. 6, 97080, Würzburg, Germany.
Anna WidderDepartment for General, Transplant, Vascular and Pediatric Surgery, University Hospital of Wuerzburg, Oberduerrbacher Str. 6, 97080, Würzburg, Germany.
Katrin SchoettkerDepartment of Internal Medicine, Division of Gastroenterology, University Hospital of Wuerzburg, Oberduerrbacher Str. 6, 97080, Würzburg, Germany.
Markus BrandDepartment of Internal Medicine, Division of Gastroenterology, University Hospital of Wuerzburg, Oberduerrbacher Str. 6, 97080, Würzburg, Germany.
Alexander MeiningDepartment of Internal Medicine, Division of Gastroenterology, University Hospital of Wuerzburg, Oberduerrbacher Str. 6, 97080, Würzburg, Germany.
Regina PistoriusDepartment for General, Transplant, Vascular and Pediatric Surgery, University Hospital of Wuerzburg, Oberduerrbacher Str. 6, 97080, Würzburg, Germany.
Joachim ReibetanzDepartment for General, Transplant, Vascular and Pediatric Surgery, University Hospital of Wuerzburg, Oberduerrbacher Str. 6, 97080, Würzburg, Germany.
Nicolas SchlegelDepartment for General, Transplant, Vascular and Pediatric Surgery, University Hospital of Wuerzburg, Oberduerrbacher Str. 6, 97080, Würzburg, Germany.
Christoph-Thomas GermerDepartment for General, Transplant, Vascular and Pediatric Surgery, University Hospital of Wuerzburg, Oberduerrbacher Str. 6, 97080, Würzburg, Germany.
Sven FlemmingDepartment for General, Transplant, Vascular and Pediatric Surgery, University Hospital of Wuerzburg, Oberduerrbacher Str. 6, 97080, Würzburg, Germany. flemming_s@ukw.de.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeRates of surgery remain relevant for localized Crohn's disease despite the evolution of novel therapies. However, the effect of immunosuppressive medication on the perioperative outcome including the extent of the resection is still inconclusive and needs to be evaluated.

methodsIn a single-center study, all patients who received ileocolic resection due to localized Crohn's disease were retrospectively assessed and divided into two groups depending on previous treatment (preoperative medication versus therapy-naïve). Outcome parameters included patient characteristics, surgical and histopathological aspects.

resultsTwo hundred thirty-seven patients were analyzed of whom 192 patients received medical treatment prior to surgery. Preoperative treatment had neither an effect on the length of the resected specimen (29.4 cm versus 27.1 cm, p = 0.27) nor on the postoperative outcome. Only rates of conversion were significantly increased for therapy-naïve patients compared to patients receiving preoperative treatment (15.6% versus 5.7%, p = 0.025).

conclusionPreoperative medical treatment does not have an effect on the extent of the resected bowel segment in patients suffering from localized Crohn's disease.

Indexed as

ColonCrohn DiseaseIleumImmunosuppressive AgentsPreoperative CareAdultFemaleHumansMaleMiddle AgedTreatment OutcomeYoung AdultImmunosuppressive AgentsColorectal surgeryCrohn’s diseaseIleocolic resectionImmunosuppressantsInflammatory bowel disease

Identifiers

PMID40471309
PMCPMC12141124

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.