Evidence map›Paper›PMID 40471294›Full record

ArticleActa diabetologica2025

Association of baseline and changes in estimated glucose disposal rate and risk of chronic kidney disease: evidence from a national longitudinal study.

Fan Zhang, Jiao Li, Xueling Li, Liuyang Huang, Yifei Zhong

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In one paragraph

Article in Acta diabetologica, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Fan Zhang *Department of Nephrology, Longhua Hospital Shanghai University of Traditional Chinese Medicine, No. 725, Wanping South Road, Xuhui District, Shanghai, China.
Jiao Li *Department of Nephrology, Longhua Hospital Shanghai University of Traditional Chinese Medicine, No. 725, Wanping South Road, Xuhui District, Shanghai, China.
Xueling LiDepartment of Nephrology, Longhua Hospital Shanghai University of Traditional Chinese Medicine, No. 725, Wanping South Road, Xuhui District, Shanghai, China.
Liuyang HuangDepartment of Nephrology, Longhua Hospital Shanghai University of Traditional Chinese Medicine, No. 725, Wanping South Road, Xuhui District, Shanghai, China.
Yifei ZhongDepartment of Nephrology, Longhua Hospital Shanghai University of Traditional Chinese Medicine, No. 725, Wanping South Road, Xuhui District, Shanghai, China. sh_zhongyifei@shutcm.edu.cn.ORCID http://orcid.org/0000-0002-2462-3064

Funding

Demonstration-oriented Research Ward Construction Project of Shanghai Hospital Development Center SHDC2022CRW006Shanghai Hospital Development Center SHDC2022CRD003
6 · The paper itself

Abstract

objectiveThis study explored the relationship between baseline estimated glucose disposal rate (eGDR), its trajectories, and the risk of chronic kidney disease (CKD).

methodsParticipants from the China Health and Retirement Longitudinal Study were included. eGDR was calculated using a validated formula, and CKD was defined as an estimated glomerular filtration rate less than 60 mL/min/1.73m2 or self-reported. Group-based trajectory modeling identified distinct eGDR patterns, and Cox proportional hazards models assessed associations between eGDR and CKD risk.

resultsA total of 5,238 participants were analyzed, with 436 incident CKD cases during the 5-year follow-up. Higher baseline eGDR (≥ 8 mg/kg/min) was associated with a reduced CKD risk (Hazard Ratio [HR] = 0.40; 95% Confidence Interval [CI]: 0.19-0.88; P = 0.022). An L-shaped relationship was observed between eGDR and CKD risk. Three eGDR trajectories were identified: low-stability (41.8%), decreasing (14.5%), and high-stability (43.7%). Only the high-stability trajectory significantly reduced CKD risk (HR = 0.77; 95% CI: 0.62-0.96; P = 0.019) compared to the low-stability group.

conclusionHigher baseline eGDR and consistently high eGDR trajectories were linked to a lower CKD risk, highlighting the significance of maintaining insulin sensitivity for CKD prevention.

Indexed as

Blood GlucoseRenal Insufficiency, ChronicAgedChinaFemaleGlomerular Filtration RateHumansLongitudinal StudiesMaleMiddle AgedProportional Hazards ModelsRisk FactorsBlood GlucoseChronic kidney diseaseEstimated glucose disposal rateInsulin resistanceTrajectory

Identifiers

PMID40471294

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.