ReviewBioprocess and biosystems engineering2025
Scale-down bioreactors-comparative analysis of configurations.
Review in Bioprocess and biosystems engineering, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
8 citing papers in PubMed.
- Allergenicity Assessment of Precision Fermentation-Derived Food Proteins.Foods (Basel, Switzerland) · 2026Review
- Thinking big in small scale: characterization of peroxidase production in Komagataella phaffii using two-compartment scale-down system.Bioprocess and biosystems engineering · 2026Article
- Metabolic Engineering Strategies for Flavonoid Biosynthesis in Saccharomyces cerevisiae: Current Advances and Future Perspectives.Biotechnology and bioengineering · 2026Review
- Development and optimization of a glycerol-based fed-batch strategy for the production of peroxidases with Komagataella phaffii under the PMicrobial cell factories · 2026Article
- Do seconds make a difference? Investigating strain-specific behavior of yeast in dynamic glucose environments.Microbial cell factories · 2026Article
- Overriding Bioprocess Perturbations With a Cell-Machine Interface for Reliable Microbial Stress-Response Control.Microbial biotechnology · 2026Article
- Engineered strains as living factories: efficient biosynthesis and modification of natural products via synthetic biology and one-pot chemical tandem reactions.Frontiers in microbiology · 2026Review
- Monitoring of the Single-Cell Behavior of anBiotech (Basel (Switzerland)) · 2025Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In large-scale bioprocesses, gradients in pH, dissolved oxygen level (DO), and substrate concentrations can decrease bioprocess efficiency. Scale-down bioreactors, be it single stirred-tank bioreactors with a special feeding regime, multi-compartment bioreactors, or combinations of bioreactors, offer a promising lab-scale solution for comprehending these gradients, as they allow adjustment of gradients without incurring high costs. However, critical challenges arise when transitioning from large-scale to scale-down bioreactors. Chief among these is realistically approaching the gradient conditions of large-scale bioreactors and choosing appropriate scale-down bioreactor configurations. This review paper begins by addressing the gradients encountered in large-scale bioreactors. Afterward, various types of scale-down bioreactors are characterized and compared, highlighting their advantages and disadvantages. The suitability of scale-down bioreactors is analyzed by examples of bioprocesses with different microorganisms and mammalian cells to underscore the complexities inherent in scale-down bioprocesses and emphasize the influence of cellular responses to these conditions. Finally, the potential of miniaturized and microfluidic bioreactors is briefly discussed for future application in scale-down studies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.