Evidence map›Paper›PMID 40471254›Full record

ArticleAnalytical and bioanalytical chemistry2025

The ENTAiLS Toolkit: an integrated workflow to perform non-targeted analysis of per- and polyfluoroalkyl substances.

Heather D Whitehead, Timothy J Buckley, Jon R Sobus, Jacqueline Bangma, Denise K MacMillan, Troy M Ferland, Alex Chao, Antony J Williams, Gregory Janesch, Regina Poeske and 13 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Analytical and bioanalytical chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Heather D WhiteheadOffice of Research and Development, U.S. Environmental Protection Agency, Washington, DC, USA. whitehead.heather@epa.gov.
Timothy J BuckleyOffice of Research and Development, U.S. Environmental Protection Agency, Washington, DC, USA.
Jon R SobusOffice of Research and Development, U.S. Environmental Protection Agency, Washington, DC, USA.
Jacqueline BangmaOffice of Research and Development, U.S. Environmental Protection Agency, Washington, DC, USA.
Denise K MacMillanOffice of Research and Development, U.S. Environmental Protection Agency, Washington, DC, USA.
Troy M FerlandOffice of Research and Development, U.S. Environmental Protection Agency, Washington, DC, USA.
Alex ChaoOffice of Research and Development, U.S. Environmental Protection Agency, Washington, DC, USA.
Antony J WilliamsOffice of Research and Development, U.S. Environmental Protection Agency, Washington, DC, USA.
Gregory JaneschOffice of Research and Development, U.S. Environmental Protection Agency, Washington, DC, USA.
Regina PoeskeU.S. Environmental Protection Agency, Region 3, Philadelphia, PA, USA.
Erin NewmanU.S. Environmental Protection Agency, Region 5, Chicago, IL, USA.
Carole BravermanU.S. Environmental Protection Agency, Region 5, Chicago, IL, USA.
Matthew SmallU.S. Environmental Protection Agency, Region 9, San Francisco, CA, USA.
Sinisa UrbanMaryland Department of Health, Baltimore, MD, USA.
Zhao CaoMaryland Department of Health, Baltimore, MD, USA.
Andri DahlmeierMinnesota Pollution Control Agency, St. Paul, MN, USA.
Stefan SaraviaMinnesota Department of Health, St. Paul, MN, USA.
Rosie RushingMinnesota Department of Health, St. Paul, MN, USA.
Marla DeVaultMinnesota Department of Health, St. Paul, MN, USA.
Wendy LinckCalifornia State Water Resources Control Board, Sacramento, CA, USA.
Erica KalveCalifornia State Water Resources Control Board, Sacramento, CA, USA.
David SchiesselBabcock Laboratories Inc, Riverside, CA, USA.
James P McCordOffice of Research and Development, U.S. Environmental Protection Agency, Washington, DC, USA. mccord.james@epa.gov.

Funding

Intramural EPA EPA999999
6 · The paper itself

Abstract

Environmental health concerns over per- and polyfluoroalkyl substances (PFAS) have prompted public health laboratories to pursue monitoring studies determining PFAS occurrences. Select laboratories have begun implementing non-targeted analysis (NTA) methods to address the disparity between the few (< 100) PFAS typically measured using targeted analyses and the thousands of known PFAS. While NTA can provide a more comprehensive understanding of PFAS occurrence, significant barriers prevent its widespread adoption in public health laboratories. Notable barriers include a lack of harmonized guidance, standardized methods, and workflows that enable robust NTA application. EPA's Office of Research and Development has been working to overcome these barriers as part of technical collaborations with state environmental and public health laboratories. As a product of these efforts, ORD has developed the ENTAiLS Toolkit, a publicly available compilation of best practices and an open-source data processing workflow for PFAS NTA studies. The ENTAiLS Toolkit offers NTA practitioners comprehensive guidance and integrated tools that can aid the identification and characterization of PFAS in drinking water resources.

Indexed as

Environmental MonitoringFluorocarbonsWater Pollutants, ChemicalDrinking WaterHumansWorkflowDrinking WaterFluorocarbonsWater Pollutants, ChemicalData processingDrinking waterNon-targeted analysisPFASWorkflows

Identifiers

PMID40471254
PMCPMC13061283

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.