Evidence map›Paper›PMID 40471087›Full record

ArticleAnnals of medicine2025

Prognostic value of baseline and absolute change of inflammatory markers in patients with thymic epithelial tumors.

Huiting Li, Boyan Wang, Donglai Chen, Yongbing Chen, Min Fan, Junmiao Wen, Jiayan Chen

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Article in Annals of medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

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4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Huiting LiDepartment of Radiation Oncology, Fudan University Shanghai Cancer Center, Department of Oncology, Shanghai Medical College, Fudan University, Shanghai Key Laboratory of Radiation Oncology, Shanghai, China.
Boyan WangDepartment of Radiation Oncology, Fudan University Shanghai Cancer Center, Department of Oncology, Shanghai Medical College, Fudan University, Shanghai Key Laboratory of Radiation Oncology, Shanghai, China.
Donglai ChenDeparment of Thoracic Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.ORCID 0000-0001-7603-4803
Yongbing ChenDepartment of Thoracic Surgery, The Second Affiliated Hospital of Soochow University, Suzhou, China.
Min FanDepartment of Radiation Oncology, Fudan University Shanghai Cancer Center, Department of Oncology, Shanghai Medical College, Fudan University, Shanghai Key Laboratory of Radiation Oncology, Shanghai, China.
Junmiao WenDepartment of Radiation Oncology, Fudan University Shanghai Cancer Center, Department of Oncology, Shanghai Medical College, Fudan University, Shanghai Key Laboratory of Radiation Oncology, Shanghai, China.
Jiayan ChenDepartment of Radiation Oncology, Fudan University Shanghai Cancer Center, Department of Oncology, Shanghai Medical College, Fudan University, Shanghai Key Laboratory of Radiation Oncology, Shanghai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThis study aims to investigate the prognostic value of baseline and absolute changes of inflammatory markers in thymic epithelial tumors (TETs).

methodsThis real-world study enrolled 147 patients. Inflammatory markers, including baseline and absolute changes of platelet-to-lymphocyte (PLR), platelet-to-monocyte (PMR), lymphocyte-to-monocyte (LMR), and neutrophil-to-lymphocyte ratio (NLR), were retrospectively collected. Survival analysis was conducted using Kaplan-Meier analysis. Lasso and multivariate Cox regression were conducted to assess the relationship between disease-free survival (DFS), overall survival (OS) and inflammatory markers. Predictive nomograms were constructed by variables identified in Cox regression.

resultsHigher baseline NLR and PLR, lower baseline LMR and PMR, a greater change in PLR and smaller changes in LMR, PMR, and PNR related to inferior DFS and OS. Multivariate Cox regression identified higher baseline PLR and advanced Masaoka Stage were risk, while higher baseline PMR was protective OS factors. Age, higher baseline PLR, and advanced Masaoka Stage were risk DFS factors. A greater absolute PLR change and metastasis were risk, while a lower absolute PMR change was protective OS factors. Age and a greater absolute PLR change were risk, while a greater absolute LMR change was favorable DFS factors.

conclusionsThe present study is the first to reveal the prognostic role of the baseline and absolute changes of inflammatory markers in TETs. The prognostic models based on these inflammatory markers offer promising tools for predicting the prognosis of TET patients.

Indexed as

Neoplasms, Glandular and EpithelialThymus NeoplasmsAdultAgedBiomarkers, TumorBlood PlateletsDisease-Free SurvivalFemaleHumansInflammationKaplan-Meier EstimateLymphocyte CountLymphocytesMaleMiddle AgedMonocytesBiomarkers, TumorInflammatory markersprognostic modelreal-world analysisthymic epithelial tumors

Identifiers

PMID40471087
PMCPMC12143014

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