ArticleJournal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine2025
Actigraphy-derived sleep fragmentation index: convergent validity and associations with clinical outcomes.
Article in Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Longitudinal Trajectories of Cognitive Control and Theory of Mind in Amnestic and Non-Amnestic Mild Cognitive Impairment: Prospective Associations of Objective Sleep Duration.Journal of clinical medicine · 2026Article
- Childhood paternal abuse and low paternal affection predict adult panic symptoms 18 years later via actigraphy-indexed sleep disruptions.Psychological medicine · 2026Article
- REM Sleep is Associated with Cognition and Biomarkers Longitudinally in Older Adults Across the Alzheimer Disease Continuum.medRxiv : the preprint server for health sciences · 2026Article
- Sleep characteristics and risk factors in patients of insomnia comorbid with anxiety.BMC psychology · 2026Article
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Authors and funding
6 authors.
Funding
Abstract
STUDY
objectivesWake after sleep onset and sleep efficiency derived from actigraphy are common assessments of sleep fragmentation (or continuity). The sleep fragmentation index (SFI), measuring the frequency of sleep-wake transitions, is less understood. This study examined (1) the convergent validity between SFI and other sleep metrics obtained by actigraphy and polysomnography; and (2) associations of SFI with sleep symptoms, obstructive sleep apnea, periodic limb movement index, and cognition (Digit Symbol Coding test).
methodsCross-sectional analysis using logistic and multiple regression analyses adjusted for potential confounders. 1,908 participants in the Multi-Ethnic Study of Atherosclerosis study who underwent 7-day actigraphy and polysomnography. The sample was 53.9% female; age 68.3 ± 9.1 years (mean ± standard deviation); apnea-hypopnea index 19.5 ± 17 events/h; and SFI 20.09 ± 6.99.
resultsHigher SFI was associated with older age, male sex, Black race, smoking, body mass index, obstructive sleep apnea, and polysomnography-based metrics of sleep architecture. SFI was strongly correlated with actigraphy-measured sleep efficiency (
conclusionsThe results support the convergent validity between actigraphy-estimated SFI and actigraphy-wake after sleep onset and sleep efficiency. SFI showed modestly stronger associations with clinical symptoms compared to other fragmentation variables, supporting its utility as a marker of sleep continuity. CITATION: Saleh D, Bertisch SM, Reid M, Lim A, Purcell S, Redline S. Actigraphy-derived sleep fragmentation index: convergent validity and associations with clinical outcomes.
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