Evidence map›Paper›PMID 40470958›Full record

ArticleJournal of virology2025

Kaposi's sarcoma-associated herpesvirus ORF61 protein sequesters APOBEC3B in filamentous aggregates.

Laura-Marie Luoto, Enrico Caragliano, Carola Schneider, Rudolph Reimer, Wolfram Brune

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of virology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Laura-Marie LuotoLeibniz Institute of Virology (LIV), Hamburg, Germany.ORCID 0009-0009-6278-4801
Enrico CaraglianoLeibniz Institute of Virology (LIV), Hamburg, Germany.ORCID 0000-0003-2193-1851
Carola SchneiderLeibniz Institute of Virology (LIV), Hamburg, Germany.
Rudolph ReimerLeibniz Institute of Virology (LIV), Hamburg, Germany.ORCID 0009-0007-6336-1371
Wolfram BruneLeibniz Institute of Virology (LIV), Hamburg, Germany.ORCID 0000-0002-6078-5255

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Herpesviruses are large DNA viruses that encode homologs of cellular enzymes. The viral ribonucleotide reductase, which consists of large R1 and small R2 subunits, is required for deoxyribonucleotide synthesis. However, herpesviruses have repurposed the R1 subunit for additional non-canonical functions in virus-host interaction and immune evasion. Here, we investigated the R1 proteins of Kaposi's sarcoma-associated herpesvirus (KSHV) and murine gammaherpesvirus 68 (MHV-68), two γ-herpesviruses of the genus

Indexed as

Cytidine DeaminaseHerpesvirus 8, HumanRhadinovirusViral ProteinsAnimalsCell LineCell NucleusCytoplasmDNA ReplicationHEK293 CellsHost-Pathogen InteractionsHumansMiceMinor Histocompatibility AntigensRibonucleotide ReductasesVirus ReplicationAPOBEC3B protein, humanCytidine DeaminaseMinor Histocompatibility AntigensRibonucleotide ReductasesViral ProteinsaggregateCLEMfibrilFRAPhuman herpesvirus 8KSHVMHV-68ribonucleotide reductase

Identifiers

PMID40470958
PMCPMC12282084

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.