Evidence map›Paper›PMID 40470957›Full record

ArticleJournal of virology2025

Inherited chromosomally integrated human herpesvirus 6: regional variation in prevalence, association with angina, and identification of ancestral viral lineages in two large UK studies.

Michael L Wood, Adam J Bell, Robin Young, Christopher Brownlie, Nick Orr, Archie Campbell, Jenna Nichols, Konstantinos Papageorgiou, Annette Lake, Nicolas M Suarez and 30 more

Abstract read
In one paragraph

Article in Journal of virology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Endogenous human herpesviruses 6A/B.Journal of virology · 2025
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

40 authors.

Michael L WoodMRC-University of Glasgow Center for Virus Research, Glasgow, United Kingdom.ORCID 0000-0003-4042-525X
Adam J BellMRC-University of Glasgow Center for Virus Research, Glasgow, United Kingdom.
Robin YoungRobertson Center for Biostatistics, School of Health and Wellbeing, University of Glasgow, Glasgow, United Kingdom.
Christopher BrownlieMRC-University of Glasgow Center for Virus Research, Glasgow, United Kingdom.
Nick OrrThe Institute of Cancer Research, London, United Kingdom.
Archie CampbellMRC Human Genetics Unit, IGC, University of Edinburgh, Edinburgh, United Kingdom.
Jenna NicholsMRC-University of Glasgow Center for Virus Research, Glasgow, United Kingdom.
Konstantinos PapageorgiouMRC-University of Glasgow Center for Virus Research, Glasgow, United Kingdom.
Annette LakeMRC-University of Glasgow Center for Virus Research, Glasgow, United Kingdom.
Nicolas M SuarezMRC-University of Glasgow Center for Virus Research, Glasgow, United Kingdom.
Katherine SmollettMRC-University of Glasgow Center for Virus Research, Glasgow, United Kingdom.
Natasha JesudasonMRC-University of Glasgow Center for Virus Research, Glasgow, United Kingdom.
Salvatore CamioloMRC-University of Glasgow Center for Virus Research, Glasgow, United Kingdom.
Sreenu VattipallyMRC-University of Glasgow Center for Virus Research, Glasgow, United Kingdom.
Joseph HughesMRC-University of Glasgow Center for Virus Research, Glasgow, United Kingdom.
Kirby BrownMRC-University of Glasgow Center for Virus Research, Glasgow, United Kingdom.
Leah M HunterMRC-University of Glasgow Center for Virus Research, Glasgow, United Kingdom.
Euan ShawMRC-University of Glasgow Center for Virus Research, Glasgow, United Kingdom.
Skye StorrieMRC-University of Glasgow Center for Virus Research, Glasgow, United Kingdom.
Rithu Paul StansilausMRC-University of Glasgow Center for Virus Research, Glasgow, United Kingdom.
Eillis SweeneyMRC-University of Glasgow Center for Virus Research, Glasgow, United Kingdom.
Tingyi ZhuMRC-University of Glasgow Center for Virus Research, Glasgow, United Kingdom.
Angie FawkesEdinburgh Clinical Research Facility, University of Edinburgh, Edinburgh, United Kingdom.
Lee MurphyEdinburgh Clinical Research Facility, University of Edinburgh, Edinburgh, United Kingdom.
William TyneSchool of Biological and Chemical Sciences, Queen Mary University of London, London, United Kingdom.
Philip HowardSchool of Biological and Chemical Sciences, Queen Mary University of London, London, United Kingdom.
Michael E JonesThe Institute of Cancer Research, London, United Kingdom.
Katarzyna TomczykThe Institute of Cancer Research, London, United Kingdom.
Anne RichmondMRC Human Genetics Unit, IGC, University of Edinburgh, Edinburgh, United Kingdom.
James F WilsonMRC Human Genetics Unit, IGC, University of Edinburgh, Edinburgh, United Kingdom.
Duncan A ClarkSchool of Infection and Immunity, University of Glasgow, Glasgow, United Kingdom.
Christian DellesSchool of Cardiovascular and Metabolic Health, University of Glasgow, Glasgow, United Kingdom.
Nicola RoyleUniversity of Leicester, Leicester, United Kingdom.
Shona M KerrMRC Human Genetics Unit, IGC, University of Edinburgh, Edinburgh, United Kingdom.
Ana da Silva FilipeMRC-University of Glasgow Center for Virus Research, Glasgow, United Kingdom.
Andrew J DavisonMRC-University of Glasgow Center for Virus Research, Glasgow, United Kingdom.ORCID 0000-0002-4991-9128
Alex McConnachieRobertson Center for Biostatistics, School of Health and Wellbeing, University of Glasgow, Glasgow, United Kingdom.
Anthony J SwerdlowThe Institute of Cancer Research, London, United Kingdom.
Caroline HaywardMRC Human Genetics Unit, IGC, University of Edinburgh, Edinburgh, United Kingdom.
Ruth F JarrettMRC-University of Glasgow Center for Virus Research, Glasgow, United Kingdom.ORCID 0000-0003-0390-3478

Funding

Chief Scientist Office, Scottish Government Health and Social Care Directorate CGA/16/31Chief Scientist Office, Scottish Government Health and Social Care Directorate CZD/16/6Medical Research Council MC_UU_00007/10Medical Research Council MC_UU_12014/12Medical Research Council MC_UU_12014/3Medical Research Council MR/T030941/1Scottish Funding Council HR03006Wellcome TrustWellcome Trust 104036/Z/14/Z
6 · The paper itself

Abstract

Tens of millions of people worldwide have inherited chromosomally integrated human herpesvirus 6 (iciHHV-6), yet we know little about the consequences. iciHHV-6-positive individuals inherit the genome of HHV-6A or HHV-6B in the germline, and viral genomes are therefore present in every nucleated cell. To investigate the epidemiology of iciHHV-6 in the UK, almost 32,000 individuals were screened from two volunteer research studies: the family-based Generation Scotland: Scottish Family Health Study (GS:SFHS) and the Breakthrough Generations Study (BGS). iciHHV-6 prevalence in GS:SFHS was, to our knowledge, higher than that in other large studies at 2.74% (647/23,637), with an iciHHV-6B prevalence of 2.55%. Scottish participants were more likely to be iciHHV-6B-positive than English (

Indexed as

Angina PectorisHerpesvirus 6, HumanRoseolovirus InfectionsVirus IntegrationAdultAgedFemaleHumansMaleMiddle AgedPrevalenceScotlandUnited Kingdomanginachromosomal integrationgeneration ScotlandherpesvirusHHV-6human herpesvirus 6iciHHV-6inherited HHV-6telomere

Identifiers

PMID40470957
PMCPMC12282103

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.