ArticleAntimicrobial agents and chemotherapy2025
Influence of patient characteristics and oral lead-in on long-acting cabotegravir and rilpivirine pharmacokinetics and outcomes in people with HIV: a real-world study.
Article in Antimicrobial agents and chemotherapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Effect of Non-nucleoside Resistance-Associated Mutations on the Effectiveness of Long-Acting Cabotegravir + Rilpivirine Therapy: Insights From the Real-World RELATIVITY Cohort.Open forum infectious diseases · 2026Article
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Authors and funding
11 authors.
Funding
Abstract
Factors influencing suboptimal pharmacokinetics (PK) of long-acting (LA) cabotegravir (CAB) and rilpivirine (RPV) in people with HIV (PWH) remain poorly understood. Lower plasma concentrations in underrepresented populations in clinical trials and direct initiation without an oral lead-in (OLI) require further investigation. This study examined CAB and RPV plasma levels in a real-world cohort, focusing on OLI's role. This prospective cohort study followed PWH transitioning from oral antiretroviral therapy to CAB + RPV injections. Participants were sequentially assigned to start with injections (SWI) or with OLI. Plasma CAB and RPV levels were measured before each injection over 7 months, with virological monitoring up to 11 months. Mixed-effects models were used to identify the predictors of lower CAB and RPV levels, adjusting for OLI use, age, sex, body mass index (BMI), and smoking. Among 172 participants (median age: 48 years, 12.8% female, 14.7% BMI ≥30 kg/m², 45.5% smokers), 81 (47.1%) initiated therapy via SWI, and 91 (52.9%) via OLI. CAB concentrations were lower in participants with higher BMI (
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